What does it mean if I have a high risk of HBOC mutation?
A high risk on the calculator means that you have met the criteria set by the National Comprehensive Cancer Network to be recommended genetic testing and counseling for HBOC. It is important to note that having a HBOC mutation is not a guarantee for developing breast, ovarian, prostate or other related cancers, but it increases the risk.
While the general population risk or baseline risk of developing breast cancer is 12%, someone with HBOC has a 80% risk of developing breast cancer. Similarly, someone affected with HBOC has a 50% lifetime risk of ovarian cancer compared to the general population average baseline risk of ovarian cancer is 1%.