Test : HAM Test/ Acid Serum Test/ PNH Test/ Paroxysmal Noctural Hemoglobinuria test, Serum lysis.
Indications : HAM test is used to evaluate patients with suspected PNH (Paroxysmal Noctural Hemoglobinuria) or suspected congential dyserythropoietic anemia, especially with hemosiderinuria, Pancytopenia, decreased RBC acetyl cholinesterase, decreased leukocyte alkaline phosphatase, negative direct Coomb’s test, and/or apparent marrow failure.
Physiology : Diagnosis of PNH shows that the suspected patient’s red cells have a high sensitivity to complement mediated hemolysis. Partial hemolysis occurs with hereditary erythroblastic multinuclearity disease. PNH is a disease of increased complement sensitivity of red ell membranes, granulocytes and platelet membrane.
Normal Range : Positive test result shows lysis of Red cells in acidified serum samples with patients cell (not with normal cells).
Test Method : Acidified Serum test of HAM.
Related Tests : Peripheral blood/ RBC Morphology/ Sugar Water test screen.
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