Although more than 60 years have passed since the discovery and first reported human cases of the zika virus, no vaccine has been developed to provide immunity from the virus successfully. Currently, there are no licensed vaccines against Zika virus infection. New DNA-based Zika vaccine called GLS-5700 had been developed. GLS-5700 contains instructions for the host to mount an immune response against Zika virus. The vaccine is found to be safe and effective.