Pertussis vaccination is contraindicated in children with progressive neurological disease and also further doses are withheld in, children who react with screaming attacks lasting for more than 1 hour after a dose of DPT. For those children, a dual antigen DT is preferred for further immunization. There has always been an element of uncertainty regarding pertussis immunization and encephalopathies. The follow-up system established in Europe and the United States do not indicate a causal relationship and convulsion following immunization is more likely febrile convulsion. DPT is not recommended in children over 6 years of age in view of side effects.
An acellular vaccine containing whole antigen has been developed and found to elicit good antibody response with fewer side effects. It has replaced the classical vaccine in Japan since 1981 with success, with fewer out breaks and less side effects.
Pertussis vaccine is contraindicated with progressive neurologic damage
Withold further doses if screaming attacks > 1 hour occurs after a dose of DPT
Not recommended over 6 years of age.
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