| Use: |
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Relief of the signs and symptoms of osteoarthritis; relief of the signs and symptoms of rheumatoid arthritis in adults
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| Pregnancy & Lactation : |
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Risk Factor - C |
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| Warnings & Precautions: |
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Gastrointestinal irritation, ulceration, bleeding, and perforation may occur with NSAIDs (it is unclear whether celecoxib is associated with rates of these events which are similar to nonselective NSAIDs). |
| Use with caution in patients with a history of GI disease (bleeding or ulcers), decreased renal function, hepatic disease, congestive heart failure, hypertension, or asthma. Anaphylactoid reactions may occur, even with no prior exposure to celecoxib.Use caution in patients with known or suspected deficiency of cytochrome P-450 soenzyme 2C9. |
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| Contraindication: |
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Hypersensitivity to celecoxib or any component, sulfonamides, aspirin, or other nonsteroidal anti-inflammatory drugs (NSAIDs) | |
| Adverse Reactions : |
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>10%: Central nervous system: Headache (15.8%).
2% to 10%: Cardiovascular: Peripheral edema (2.1%) Central nervous system: Insomnia (2.3%), dizziness (2%) Dermatologic: Skin rash (2.2%) Gastrointestinal: Dyspepsia (8.8%), diarrhea (5.6%), abdominal pain (4.1%), nausea (3.5%), flatulence (2.2%) Neuromuscular & skeletal: Back pain (2.8%) Respiratory: Upper respiratory tract infection (8.1%), sinusitis (5%), pharyngitis (2.3%), rhinitis (2%) Miscellaneous: Accidental injury (2.9%) | |
Interactions : |
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Decreased effect: Efficacy of thiazide diuretics, loop diuretics (furosemide), or ACE-inhibitors may be diminished by celecoxib; aluminum and magnesium-containing antacids may decrease AUC and Cmax of celecoxib 10% and 37% respectively
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| Increased effect: Fluconazole increases celecoxib concentrations two-fold. Lithium concentrations may be increased by celecoxib. Celecoxib may be used with low-dose aspirin, however rates of gastrointestinal bleeding may be increased with coadministration. Celecoxib has not been shown to alter warfarin effects, although bleeding complications may be increased. b | |
Over Dose / Poisoning : |
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Symptoms may include epigastric pain, drowsiness, lethargy, nausea, and vomiting; gastrointestinal bleeding may occur. Rare manifestations include hypertension, respiratory depression, coma, and acute renal failure.Treatment is symptomatic and supportive; forced diuresis, hemodialysis and/or urinary alkalinization may not be useful. | |
Dosage : |
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Adults: Oral: Osteoarthritis: 200 mg/day as a single dose or in divided dose twice daily .Rheumatoid arthritis: 100-200 mg twice daily .Dosing adjustment in renal impairment: No specific dosage adjustment is recommended .Dosing adjustment in hepatic impairment: Reduced dosage is recommended (AUC may be increased by 40% to 180%) .Dosing adjustment for elderly: No specific adjustment is recommended. However, the AUC in elderly patients may be increased by 50% as compared to younger subjects. Use the lowest recommended dose in patients weighing <50 kg. |
Patient Information : |
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Do not take more than recommended dose. May be taken with food to reduce GI upset. Do not take with antacids. Avoid alcohol, aspirin, and OTC medication unless approved by prescriber. You may experience dizziness, confusion, or blurred vision (avoid driving or engaging in tasks requiring alertness until response to drug is known); anorexia, nausea, vomiting, taste disturbance, gastric |
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distress (small frequent meals, frequent mouth care, sucking lozenges, or chewing gum may help). GI bleeding,mulceration, or perforation can occur with or without pain; it is unclear whether celecoxib has rates of these events which are similar to nonselective NSAIDs. Stop taking medication and report immediately stomach pain or cramping, unusual bleeding or bruising, or blood in vomitus, stool, or urine. Report persistent insomnia; skin rash; unusual fatigue or easy bruising or bleeding; muscle pain, tremors, or weakness; sudden weight gain; changes in hearing (ringing in ears); changes in vision; changes in urination pattern; or respiratory difficulty. Pregnancy/breast-feeding precautions: Inform prescriber if you are or intend to be pregnant. Consult prescriber if breast-feeding.
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Comments
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