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Drug information on BROPHYLE (Acebrophylline) from Zuventus Healthcare.

BROPHYLE

  Capsule
Zuventus Healthcare.
Generic : Acebrophylline
 80.20
100mg
10
Vijayaganesh Kasinathan
Written & Compiled by Pharmacist Vijayaganesh Kasinathan, B.Pharm, M.Pharm
Dr. Simi Paknikar
Medically Reviewed by Dr. Simi Paknikar, MD
Last Updated on Sep 19, 2017
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Medical Condition(s) for which BROPHYLE may be prescribed


Overview of BROPHYLE

• Acebrophylline is used for its mucoregulative action and anti-inflammatory properties in the respiratory tract.

Side effects of BROPHYLE

  Gastro-intestinal: Abdominal discomfort, esophageal bleeding, vomiting, diarrhea, constipation, loss of appetite

  Central Nervous System: Headache, drowsiness

  Respiratory: Difficulty or shortness in breathing

  Skin: Rashes, itching

  Others: Fever with chills, elevated white blood cell count, changes in blood pressure, numbness in the arm

Dosage & When it is to be taken (Indications)

• The recommended dosage for adults in treating COPD and bronchial asthma is 100 mg twice daily.

• Child dosage of acebrophylline syrup (50mg/5ml):

Below 2 years of age : 2.5 ml twice daily
2 - 5 years of age : 2.5ml three times daily
Above 5 years : 5 ml twice daily or as directed by the physician

How to use BROPHYLE?

• Acebrophylline is available in the form of a capsule, tablet and syrup.
• This drug should be taken orally with food to avoid gastric discomfort.

When is BROPHYLE not to be taken? (Contraindications)

Contraindicated in patients in:

• Allergy to xanthine derivatives and ambroxol
• Low blood pressure or heart attack or abnormal heart rhythms
• Liver or kidney impairment

Warnings and Precautions for BROPHYLE

Special precautions should be observed in patients suffering from seizures, cardiac insufficiency and gastro-intestinal disorders.

• Acebrophylline-induced angioedema , a serious allergic reaction, could occur

• Caution is advised in patients with hyperthyroidism, that is, high thyroid hormone levels since it can cause cardiac side effects

Other Precautions for BROPHYLE

• Avoid excess dosage.

Drug Interactions of BROPHYLE

Acebrophylline could be involved in the following drug interactions:

• Plasma concentration of acebrophylline may be increased with the concomitant administration of drugs like quinolones, cimetidine, erythromycin, oxytetracycline, lincomycin, and cephalexin
• Interaction with reserpine results in an increase in heart rate. Reserpine though, is rarely used nowadays
• Barbiturates such as phenytoin may reduce the plasma concentration and therefore the effectiveness of acebrophylline
• Concomitant use with frusemide increases diuresis, as a result of which the patient will have to pass urine more often
• Acebrophylline can worsen low blood potassium levels caused by drugs like steroids

Storage Conditions for BROPHYLE

• Store in a cool, dry place. Protect from heat and moisture.
• Keep away from the reach of children.



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