â€¢ Acebrophylline is used for its mucoregulative action and anti-inflammatory properties in the respiratory tract.
â€¢ Gastro-intestinal: Abdominal discomfort, esophageal bleeding, vomiting, diarrhea, constipation, loss of appetite
â€¢ Central Nervous System: Headache, drowsiness
â€¢ Respiratory: Difficulty or shortness in breathing
â€¢ Skin: Rashes, itching
â€¢ Others: Fever with chills, elevated white blood cell count, changes in blood pressure, numbness in the arm
â€¢ The recommended dosage for adults in treating COPD and bronchial asthma is 100 mg twice daily.
â€¢ Child dosage of acebrophylline syrup (50mg/5ml):
Below 2 years of age : 2.5 ml twice daily
2 - 5 years of age : 2.5ml three times daily
Above 5 years : 5 ml twice daily or as directed by the physician
â€¢ Acebrophylline is available in the form of a capsule, tablet and syrup.
â€¢ This drug should be taken orally with food to avoid gastric discomfort.
â€¢ Special precautions should be observed in patients suffering from seizures, cardiac insufficiency and gastro-intestinal disorders.
â€¢ Acebrophylline-induced angioedema , a serious allergic reaction, could occur
â€¢ Caution is advised in patients with hyperthyroidism, that is, high thyroid hormone levels since it can cause cardiac side effects
â€¢ Avoid excess dosage.
Acebrophylline could be involved in the following drug interactions:
â€¢ Plasma concentration of acebrophylline may be increased with the concomitant administration of drugs like quinolones, cimetidine, erythromycin, oxytetracycline, lincomycin, and cephalexin
â€¢ Interaction with reserpine results in an increase in heart rate. Reserpine though, is rarely used nowadays
â€¢ Barbiturates such as phenytoin may reduce the plasma concentration and therefore the effectiveness of acebrophylline
â€¢ Concomitant use with frusemide increases diuresis, as a result of which the patient will have to pass urine more often
â€¢ Acebrophylline can worsen low blood potassium levels caused by drugs like steroids
â€¢ Store in a cool, dry place. Protect from heat and moisture.
â€¢ Keep away from the reach of children.
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