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Drug information on AB PHYLLINE (Acebrophylline) from Sun Pharmaceuticals Industries Ltd.

AB PHYLLINE   Capsule Sun Pharmaceuticals Industries Ltd. Generic : Acebrophylline	81.50 100mg 10

Written & Compiled by Pharmacist Vijayaganesh Kasinathan, B.Pharm, M.Pharm

Medically Reviewed by Dr. Simi Paknikar, MD

Last Updated on Sep 19, 2017

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Acute Bronchitis

Asthma

Bronchiectasis

Lung Cancer

Tuberculosis

Tuberous Sclerosis

• Acebrophylline is used for its mucoregulative action and anti-inflammatory properties in the respiratory tract.

•  Gastro-intestinal: Abdominal discomfort, esophageal bleeding, vomiting, diarrhea, constipation, loss of appetite

•  Central Nervous System: Headache, drowsiness

•  Respiratory: Difficulty or shortness in breathing

•  Skin: Rashes, itching

•  Others: Fever with chills, elevated white blood cell count, changes in blood pressure, numbness in the arm

• The recommended dosage for adults in treating COPD and bronchial asthma is 100 mg twice daily.

• Child dosage of acebrophylline syrup (50mg/5ml):

Below 2 years of age : 2.5 ml twice daily
2 - 5 years of age : 2.5ml three times daily
Above 5 years : 5 ml twice daily or as directed by the physician

• Acebrophylline is available in the form of a capsule, tablet and syrup.
• This drug should be taken orally with food to avoid gastric discomfort.

Contraindicated in patients in:

• Allergy to xanthine derivatives and ambroxol
• Low blood pressure or heart attack or abnormal heart rhythms
• Liver or kidney impairment

• Special precautions should be observed in patients suffering from seizures, cardiac insufficiency and gastro-intestinal disorders.

• Acebrophylline-induced angioedema , a serious allergic reaction, could occur

• Caution is advised in patients with hyperthyroidism, that is, high thyroid hormone levels since it can cause cardiac side effects

• Avoid excess dosage.

Acebrophylline could be involved in the following drug interactions:

• Plasma concentration of acebrophylline may be increased with the concomitant administration of drugs like quinolones, cimetidine, erythromycin, oxytetracycline, lincomycin, and cephalexin
• Interaction with reserpine results in an increase in heart rate. Reserpine though, is rarely used nowadays
• Barbiturates such as phenytoin may reduce the plasma concentration and therefore the effectiveness of acebrophylline
• Concomitant use with frusemide increases diuresis, as a result of which the patient will have to pass urine more often
• Acebrophylline can worsen low blood potassium levels caused by drugs like steroids

• Store in a cool, dry place. Protect from heat and moisture.
• Keep away from the reach of children.