Sulfadimerazine, sulfadimezine, sulphadimethylpyrimidine
• Sulfadimidine is a short-acting antibacterial agent.
• These medicines are grouped under synthetic antimicrobial agents that contain the sulfonamide group.
• These are commonly called as sulfa drugs.
Sulfadimidine is prescribed to treat urinary tract infections, prostatitis (infection of the prostate gland) and respiratory tract infections caused by bacteria.
It is capable of inhibiting the growth or reproduction of bacteria but not killing the bacteria.
It blocks the synthesis of bacterial dihydrofolic acid and therefore inhibits the growth of bacteria.
• Sulfadimidine should not be used in patients suffering from porphyria, a disorder with an excess chemical called porphyrin that affects nervous system and skin.
• It is not recommended in kidney failure patients because the drug is rapidly excreted in urine.
• Patients with G6PD (glucose 6 phosphate dehydrogenase) deficiency should not take sulfadimidine because of the occurrence of blood disorders such as anemia, agranulocytosis, hemolytic anemia and thrombocytopenia.
• It should not be used in patients allergic to the drug.
• The recommended adult dose is 0.5 g to 1 g taken three or four times daily.
• Sulfadimidine comes as a tablet or suspension to be taken by mouth with food to avoid gastric discomfort.
• Antacids reduce the absorption of sulfadimidine, therefore antacids should be taken after 2 hours from sulfadimidine administration.
• Caution is needed in newborns as sulfadimidine induces jaundice by displacing bilirubin (bile pigment) from its binding protein.
• Use with caution in individuals with kidney or liver disease.
• Skin: Allergic reactions such as rashes, itching and rarely causes serious skin reactions like Stevens-Johnson-Syndrome and epidermal necrolysis.
• Gastrointestinal: Diarrhea, nausea and vomiting.
• Blood: Anemia, agranulocytosis (low white blood cell count), hemolytic anemia (anemia that occurs due to the rupture of red blood cell) and thrombocytopenia (reduced platelet count) in patients with glucose-6-phosphate deficiency.
• Others: Crystalluria (cloudy urine), pancreatitis, hepatitis, cholestatic jaundice, and fever.
• A complete blood cell count should be monitored during the therapy to detect for various blood disorders.
• Drugs such as ascorbic acid increase the risk of crystalluria.
• The toxicity of methotrexate is increased by sulfadimidine.
• Metabolism of phenytoin, tolbutamide, and warfarin are inhibited by sulfadimidine resulting in accumulation of these drugs in the body.
• Clozapine, an antipsychotic drug taken together with sulfadimidine could increase the chances of blood problems.
• Stored at room temperature away from light and moisture.
• Keep out of reach of children.
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