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Diclofenac - Indications, Dosage, Side Effects and Precautions

Last Updated on Jan 12, 2018
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Information about Diclofenac

Generic Name : Diclofenac
Pronunciation : dye-KLOE-fen-ak
Latest prescription information about Diclofenac. Learn how to pronounce the drug's name, its indications, dosage, how to take, when to take, when not to take, side effects, special precautions, warnings and its storage instructions . Also listed are the International and Indian trade name(s) of the drug and its price list.
ICD Code : Y45.3 | Therapeutic Classification : Analgesics
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Trade Names/Brand Names of Diclofenac

India : 

More...

International : 

Voltaren, Cataflam, Dyloject, Zorvolex, Cambia, Zipsor
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Overview of Diclofenac

Diclofenac is a non-steroidal anti-inflammatory drug (NSAID) which is used to treat mild-to-moderate pain, fever, and inflammation.

Why is Diclofenac Prescribed? (Indications)

This medication is a non-steroidal anti-inflammatory drug (NSAID) prescribed to treat mild-to-moderate musculoskeletal pain.

It helps to relieve:



 

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When should Diclofenac not be taken? (Contraindications)

Diclofenac is not recommended in patients with the following conditions-

Allergy to diclofenac or any other related NSAID
Asthma or breathing problems
History of peptic ulcer or stomach bleeding
Severe kidney or liver disease
Reported allergic reaction after taking aspirin
Treating pain in coronary artery bypass graft (CABG)
Fluid retention or edema

The use of diclofenac in pregnancy should be avoided particularly in the third trimester to avoid premature closure of ductus arteriosus. Diclofenac is also not recommended during breastfeeding or during labor.

What is the dosage of Diclofenac?

Oral dose:
The recommended adult dose of diclofenac sodium or potassium is 25 mg to 50 mg three times a day after food.
The maximum daily dose is 150 mg once daily after food.
The dose of diclofenac sodium extended-release tablets is 100 mg once daily.
The maximum daily dose in treating rheumatoid arthritis is 225 mg after food.

Parenteral dose:
The prescribed adult dose is 37.5 mg to be administered intravenously for every 6 to 8 hours.
The maximum daily dose is 150 mg once daily.

Eye drops:
Instill 1 drop into the affected eye 4 times a day or as directed by the ophthalmologist. Do not use soft contact lenses while using diclofenac drops.

Topical application:
Apply diclofenac gel or cream or spray twice daily to the affected part or as directed by the physician. Do not apply on broken skin. A diclofenac patch is also available, which should be removed while bathing.

Suppositories:
Adults Dose:
Diclofenac suppositories should be inserted into the rectum one to three times daily with the maximum daily dose of 150mg.
Child Dose:
The dose of diclofenac suppositories vary with the age but usually between 1 and 3 mg/kg body weight daily in two or three divided doses.

How should Diclofenac be taken?

Diclofenac tablets for oral use should be taken by mouth along with food to avoid gastric discomfort.
Granules of diclofenac are taken by mixing the granules with sufficient quantity of water and swallowed immediately.
Do not chew, crush or break the contents of enteric-coated or film-coated tablets.

What are the warnings and precautions for Diclofenac?

While administering the intravenous injection, it is necessary to hydrate the patient in order to reduce the risk of adverse effects on the kidney.
Caution is required in patients with mild liver or kidney impairment but diclofenac should not be used in moderate-or-severe damage.

It is usually advised to start with the lowest effective dose and a treatment for a short duration if possible.
Patients should be monitored for the signs and symptoms of stomach bleeding during diclofenac therapy because of the risk of developing a peptic ulcer.
Monitor for the blood counts, kidney and liver function and blood pressure regularly in patients on long-term treatment with diclofenac.

Diclofenac may increase the risk of heart attack or stroke.
The use of another NSAID along with diclofenac is not recommended but diclofenac can be used in combination with opioids in case of severe pain or swelling.

Alcohol intake with diclofenac is not encouraged because of the increased risk of stomach bleeding or ulcer.
Treatment with diclofenac should be discontinued immediately and when serious skin reactions occur.

A high injectable dose should be avoided in patients with cardiovascular disease or uncontrolled hypertension. Injectable diclofenac should also not be administered to patients with dehydration, bleeding problems or at a high risk of bleeding.

What are the side effects of Diclofenac?

  Gastrointestinal: Nausea, constipation, flatulence, pain in the abdomen, indigestion, vomiting, bleeding and ulcers in the stomach
  Cardiovascular: Heart failure, fluid accumulation, palpitations, chest pain, high blood pressure
  Central nervous system: Dizziness, headache, hallucination, drowsiness
  Respiratory: Upper respiratory infection, sinusitis, bronchitis, nasopharyngitis, shortness of breath
  Skin: Rashes, itching, increased sweating, exfoliative dermatitis, urticaria, Stevens-Johnson syndrome, toxic epidermal necrolysis
  Genitourinary: Abnormal kidney function, raised concentrations of serum creatinine, urinary tract infection
  Others: Anemia, ringing sensation in the ears, raised level of liver enzymes, liver damage, prolongation in bleeding time, reduced blood counts, allergic reactions

What are the other precautions for Diclofenac?

Patients should be advised not to interchange the formulations of diclofenac for their treatment as the formulations may not be bioequivalent.
It is recommended to report to the emergency center any signs and symptoms of allergic reactions, gastrointestinal complaints, cardiovascular events, liver toxicity, unusual weight gain or weight loss.

What are the Drug Interactions of Diclofenac?

Concomitant administration of diclofenac and aspirin or other NSAIDs is not advised because of the risk of increased adverse effects.
Drugs such as methotrexate and cyclosporine should not be taken with diclofenac to avoid the potential for kidney toxicity.

Diclofenac may decrease the antihypertensive effects of blood pressure lowering medications including ACE inhibitors such as lisinopril, enalapril, perindopril, and ramipril when taken together.
Diclofenac may reduce the natriuretic (sodium-losing) effects of frusemide and thiazide diuretics and patients must be monitored for signs and symptoms of renal failure.
Warfarin when taken with diclofenac results in a serious risk of gastrointestinal bleeding.
Lithium when taken concomitantly with diclofenac results in the elevation of plasma lithium levels and reduced renal lithium clearance.

Enzyme inducers like rifampicin may reduce the blood levels of diclofenac, while enzyme inhibitors like voriconazole may increase its level.

What are the storage conditions for Diclofenac?

Store at a controlled room temperature between 20C and 25C.
Keep away from excess light and moisture.
Keep out of the reach of children.

Last Updated : 1/12/2018
Learn more about Diclofenac's interaction with Food, Herbs and Alcohol



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