Pallavi Singh
Written & Compiled by Pharmacist Pallavi Singh, M. Pharmacy (Pharmacy Practice)
Suchitra Chari
Medically Reviewed by Suchitra Chari, M.S. M.Sc.
Last Updated on Nov 14, 2017
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General Information on Ceftizoxime

Generic Name : Ceftizoxime

Pronunciation : Cef-ti-zo-xi-me

Latest prescription information about Ceftizoxime. Learn how to pronounce the drug's name, its indications, dosage, how to take, when to take, when not to take, side effects, special precautions, its storage instructions and warnings if any when taken during pregnancy. Also listed are the International and Indian trade name(s) of the drug and its price list.
Therapeutic Classification : Antibiotics

Trade Names/Brand Names of Ceftizoxime

Overview of Ceftizoxime

• Ceftizoxime is a semisynthetic third generation cephalosporin antibiotic particularly used in treating a wide range of bacterial infections.

Why is Ceftizoxime Prescribed? (Indications)

Ceftizoxime is active against a wide range of gram-positive and gram-negative organisms and is used in the treatment of lower respiratory tract infections, gonorrhea, pelvic inflammatory disease that also has appropriate antichlamydial coverage, intra abdominal infections, septicemia, skin infections, bone and joint infections, and in infections that are resistant to other cephalosporins, aminoglycosides, or penicillins.

Ceftizoxime belongs to the third generation cephalosporin antibiotic class. It is resistant to a board spectrum of beta-lactamases. It acts by interfering with the last step (cross-linking of peptidoglycans) of cell wall synthesis in bacteria. This leads to a reduction of cell wall stability and leads to cell lysis.

Ceftizoxime sodium is the sodium salt form of ceftizoxime. 

When should Ceftizoxime not to be taken? (Contraindications)

• It is contraindicated in patients who are allergic to ceftizoxime.

What is the dosage of Ceftizoxime?

The recommended dose of ceftizoxime is determined by the condition of the patient, severity of the infection, and susceptibility of the causative organisms.

Intravenous solution constitution is 1g/50 ml or 2g/50ml

Adults Dose:
Uncomplicated gonorrhea: 1 g intramuscular as a single dose.
Skin and intra-abdominal infections: 1 g intravenous/intramuscular every 8-12 hours
Meningitis: 1 g intravenous/intramuscular every 8 hours or 2 g intravenous/intramuscular every 8-12 hours
Urinary Tract Infection: 1-2 g intravenous/intramuscular every 8-12 hours

Dosage for children is 100-200mg/kg/day every 6-8 hours and for patients with renal impairment with creatinine clearance < 50 mL/min, the loading dose is 0.5-1 g.

How should Ceftizoxime be taken?

• This injection is taken through muscles or vein.
• Intravenous infusion should be administered either as a continuous or intermittent infusion over 15 to 30 min.

What are the warnings and precautions for Ceftizoxime?

• Caution should be taken in the patient with a history of gastrointestinal disease, especially colitis.
• It should be used carefully in patients with hypersensitivity to cephalosporin and penicillin drugs. The patient should be regularly monitored for hypersensitivity.
• If the patients are given the maximum dose for a severe illness he/she should be monitored for renal function.

What are the side effects of Ceftizoxime?

  General: Pain at injection site, numbness
  Gastrointestinal: Pseudomembranous colitis (inflammation of the colon with watery or bloody diarrhea)
  Hematologic: Eosinophilia, thrombocytosis
  Skin: Maculopapular rash, pruritus
  Other: Hypersensitivity reactions, elevated temperature.

What are the other precautions for Ceftizoxime?

• Contact doctor if you observe bloody or watery stool
• Entire course of the medication should be finished
• Prothrombin activity should be monitored in patients with kidney problems, liver problems, and malnutrition

What are the Drug Interactions of Ceftizoxime?

• Drug that interact with ceftizoxime are aminoglycosides and probenecid.

What are the storage conditions for Ceftizoxime?

• Store below 20°C, keep out of reach of children.

Last Updated : 11/14/2017

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