• Ceftizoxime is a semisynthetic third generation cephalosporin antibiotic particularly used in treating a wide range of bacterial infections.
Ceftizoxime is active against a wide range of gram-positive and gram-negative organisms and is used in the treatment of lower respiratory tract infections, gonorrhea, pelvic inflammatory disease that also has appropriate antichlamydial coverage, intra abdominal infections, septicemia, skin infections, bone and joint infections, and in infections that are resistant to other cephalosporins, aminoglycosides, or penicillins.
Ceftizoxime belongs to the third generation cephalosporin antibiotic class. It is resistant to a board spectrum of beta-lactamases. It acts by interfering with the last step (cross-linking of peptidoglycans) of cell wall synthesis in bacteria. This leads to a reduction of cell wall stability and leads to cell lysis.
Ceftizoxime sodium is the sodium salt form of ceftizoxime.
• It is contraindicated in patients who are allergic to ceftizoxime.
The recommended dose of ceftizoxime is determined by the condition of the patient, severity of the infection, and susceptibility of the causative organisms.
Intravenous solution constitution is 1g/50 ml or 2g/50ml
• Uncomplicated gonorrhea: 1 g intramuscular as a single dose.
• Skin and intra-abdominal infections: 1 g intravenous/intramuscular every 8-12 hours
• Meningitis: 1 g intravenous/intramuscular every 8 hours or 2 g intravenous/intramuscular every 8-12 hours
• Urinary Tract Infection: 1-2 g intravenous/intramuscular every 8-12 hours
Dosage for children is 100-200mg/kg/day every 6-8 hours and for patients with renal impairment with creatinine clearance < 50 mL/min, the loading dose is 0.5-1 g.
• This injection is taken through muscles or vein.
• Intravenous infusion should be administered either as a continuous or intermittent infusion over 15 to 30 min.
• Caution should be taken in the patient with a history of gastrointestinal disease, especially colitis.
• It should be used carefully in patients with hypersensitivity to cephalosporin and penicillin drugs. The patient should be regularly monitored for hypersensitivity.
• If the patients are given the maximum dose for a severe illness he/she should be monitored for renal function.
• General: Pain at injection site, numbness
• Gastrointestinal: Pseudomembranous colitis (inflammation of the colon with watery or bloody diarrhea)
• Hematologic: Eosinophilia, thrombocytosis
• Skin: Maculopapular rash, pruritus
• Other: Hypersensitivity reactions, elevated temperature.
• Contact doctor if you observe bloody or watery stool
• Entire course of the medication should be finished
• Prothrombin activity should be monitored in patients with kidney problems, liver problems, and malnutrition
• Drug that interact with ceftizoxime are aminoglycosides and probenecid.
• Store below 20°C, keep out of reach of children.
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