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Ceftizoxime is active against a wide range of gram-positive and gram-negative organisms and is used in the treatment of lower respiratory tract infections, gonorrhea, pelvic inflammatory disease that also has appropriate antichlamydial coverage, intra abdominal infections, septicemia, skin infections, bone and joint infections, and in infections that are resistant to other cephalosporins, aminoglycosides, or penicillins.

Ceftizoxime belongs to the third generation cephalosporin antibiotic class. It is resistant to a board spectrum of beta-lactamases. It acts by interfering with the last step (cross-linking of peptidoglycans) of cell wall synthesis in bacteria. This leads to a reduction of cell wall stability and leads to cell lysis.

Ceftizoxime sodium is the sodium salt form of ceftizoxime. 

Drug information on Cefizox (500mg) (Ceftizoxime) from Glaxo SmithKline Pharmaceuticals Ltd.

Cefizox (500mg)

Glaxo SmithKline Pharmaceuticals Ltd.
Generic : Ceftizoxime
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Medical Condition(s) for which Cefizox (500mg) may be prescribed

Overview of Cefizox (500mg)

• Ceftizoxime is a semisynthetic third generation cephalosporin antibiotic particularly used in treating a wide range of bacterial infections.

Side effects of Cefizox (500mg)

  General: Pain at injection site, numbness

  Gastrointestinal: Pseudomembranous colitis (inflammation of the colon with watery or bloody diarrhea)

  Hematologic: Eosinophilia, thrombocytosis

  Skin: Maculopapular rash, pruritus

  Other: Hypersensitivity reactions, elevated temperature.

Dosage & When it is to be taken (Indications)

The recommended dose of ceftizoxime is determined by the condition of the patient, severity of the infection, and susceptibility of the causative organisms.

Intravenous solution constitution is 1g/50 ml or 2g/50ml

Adults Dose:
Uncomplicated gonorrhea: 1 g intramuscular as a single dose.
Skin and intra-abdominal infections: 1 g intravenous/intramuscular every 8-12 hours
Meningitis: 1 g intravenous/intramuscular every 8 hours or 2 g intravenous/intramuscular every 8-12 hours
Urinary Tract Infection: 1-2 g intravenous/intramuscular every 8-12 hours

Dosage for children is 100-200mg/kg/day every 6-8 hours and for patients with renal impairment with creatinine clearance < 50 mL/min, the loading dose is 0.5-1 g.

How to use Cefizox (500mg)?

• This injection is taken through muscles or vein.
• Intravenous infusion should be administered either as a continuous or intermittent infusion over 15 to 30 min.

When is Cefizox (500mg) not to be taken? (Contraindications)

• It is contraindicated in patients who are allergic to ceftizoxime.

Warnings and Precautions for Cefizox (500mg)

• Caution should be taken in the patient with a history of gastrointestinal disease, especially colitis.
• It should be used carefully in patients with hypersensitivity to cephalosporin and penicillin drugs. The patient should be regularly monitored for hypersensitivity.
• If the patients are given the maximum dose for a severe illness he/she should be monitored for renal function.

Other Precautions for Cefizox (500mg)

• Contact doctor if you observe bloody or watery stool
• Entire course of the medication should be finished
• Prothrombin activity should be monitored in patients with kidney problems, liver problems, and malnutrition

Drug Interactions of Cefizox (500mg)

• Drug that interact with ceftizoxime are aminoglycosides and probenecid.

Storage Conditions for Cefizox (500mg)

• Store below 20°C, keep out of reach of children.

Disclaimer : The Price of the drugs indicated above may not match the actual price at which they are sold. Prices can change depending on many factors, including GST. These are only approximate indicative prices of the drug.
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