In some conditions such as prolonged immobility, clots may form within blood vessels. Clot formation in deep veins is called deep vein thrombosis. These clots block the flow of blood in the particular area. They may also dislodge and block blood supply to important organs such as lungs or brain resulting in a stroke or the heart leading to a heart attack. Drugs used to prevent clot formation are called anticoagulants or blood thinners. They should be differentiated from drugs such as aspirin and clopidogrel that prevent the formation of a platelet plug and are referred to as anti-platelet drugs.
Anticoagulants are of two types depending on their route of administration.
► Injectable anticoagulants – These include heparin, low molecular weight heparin, fondaparinux, lepirudin, bivalirudin, argatroban, danaparoid and drotrecogin alfa
► Oral anticoagulant tablets – The main oral anticoagulant tablet used is warfarin. A number of new drugs are undergoing testing before being introduced into the market.
Some anticoagulants are used to prevent clotting of blood when it is collected either for transfusion or blood tests. These include heparin, sodium citrate, sodium oxalate and sodium edetate.
Latest Publications and Research on AnticoagulantsDiagnostics and treatment of thrombotic antiphospholipid syndrome (APS): A personal perspective. - Published by PubMed
Diagnostics and treatment of thrombotic antiphospholipid syndrome (APS): A personal perspective. - Published by PubMed
Antiplatelet and anticoagulant agents for primary prevention of thrombosis in individuals with antiphospholipid antibodies. - Published by PubMed
Evaluation of Potential Drug-Drug Interactions With Direct Oral Anticoagulants in a Large Urban Hospital. - Published by PubMed
Antithrombotic potential of esculin 7, 3', 4', 5', 6'-O-pentasulfate (EPS) for its role in thrombus reduction using rat thrombosis model. - Published by PubMed