Alteplase - Indications, Dosage, Side Effects and Precautions

Alteplase Medication Information

Discover comprehensive details about Alteplase, including its pronunciation, uses, dosage instructions, indications, and guidelines on how and when to take it or avoid it.

The updated prescription information covers potential side effects, precautions, warnings, and storage recommendations.

Additionally, explore the Alteplase brands available in India and internationally, along with pricing information. For personalized advice, consult your healthcare provider.

Generic Name : Alteplase

Pronunciation : AL-teh-PLACE

ICD Code : Y43.6 Therapeutic Classification : Enzymes

Brand Names or Trade Names of Alteplase

India :

Actilyse Vial.

International :

Cathflo Activase

Why is Alteplase Prescribed? (Indications)

This medication is an enzyme (tissue plasminogen activator (tPA)), prescribed for heart attack, stroke, and pulmonary embolism. It helps to break down unwanted blood clots.

When should Alteplase not be taken? (Contraindications)

Contraindicated in patients with recent surgery or trauma, bleeding within the brain, uncontrolled high blood pressure, clotting defects, aneurysm or tumor in brain and active bleeding.

What is the dosage of Alteplase?

Adult: Acute massive pulmonary embolism- Total dose: 100 mg (not >1.5 mg/kg for patients weighing <65 kg). 10 mg as bolus, followed by infusion of the remainder dose over 2 hour.
Acute stroke: 0.9 mg/kg (not more than 90 mg) IV over 1 hour. The first 10% should be administered in 1 minute.
Heart attack: For patients weighing > 67 kg, 15 mg iv, followed by 50 mg over the next half an hour, and then 35 mg over the next 1 hour. The total dose of 100 mg may also be administered over 3 hours.

How should Alteplase be taken?

It comes as a solution for injection, to be injected by a healthcare provider into the vein.

What are the warnings and precautions for Alteplase?

•It may lead to serious bleeding, contact your doctor immediately.

Caution should be exercised in children, elderly, pregnant women, and patients with kidney disease.

Monitor for intracranial bleeding and blood pressure in acute stroke.

What are the side effects of Alteplase?

Potentially Fatal- Bleeding in the brain.
Heart - Heart failure, abnormal heart rhythm and heart arrest.
Central Nervous System - Cerebral edema (increased fluid content in the brain).
Miscellaneous- Allergic reactions, nausea, vomiting, low blood pressure and fever.

What are the other precautions for Alteplase?

Caution needed when administered with other drugs such as heparin and aspirin.

What are the storage conditions for Alteplase?

Injection: Store it at room temperature (<30°C) or under refrigeration.

Q: Who should not take Alteplase?

A: Patients who have recently experienced a stroke, internal bleeding, haemorrhage, head trauma, or intracranial or intraspinal surgery in the last three months are advised not to take alteplase. Those who currently have severe, uncontrolled hypertension, are advised against alteplase as well().

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