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Alteplase - Indications, Dosage, Side Effects and Precautions

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Information about Alteplase

Generic Name : Alteplase
Pronunciation : AL-teh-PLACE
Latest prescription information about Alteplase. Learn how to pronounce the drug's name, its indications, dosage, how to take, when to take, when not to take, side effects, special precautions, warnings and its storage instructions . Also listed are the International and Indian trade name(s) of the drug and its price list.
ICD Code : Y43.6 | Therapeutic Classification : Enzymes
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Trade Names/Brand Names of Alteplase

India- Actilyse Vial.
International- Cathflo Activase.
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Why is Alteplase Prescribed? (Indications)

This medication is an enzyme (tissue plasminogen activator (tPA)), prescribed for heart attack, stroke, and pulmonary embolism. It helps to break down unwanted blood clots.  

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When should Alteplase not be taken? (Contraindications)

Contraindicated in patients with recent surgery or trauma, bleeding within the brain, uncontrolled high blood pressure, clotting defects, aneurysm or tumor in brain and active bleeding.

What is the dosage of Alteplase?

Adult: Acute massive pulmonary embolism- Total dose: 100 mg (not >1.5 mg/kg for patients weighing <65 kg). 10 mg as bolus, followed by infusion of the remainder dose over 2 hour.
Acute stroke: 0.9 mg/kg (not more than 90 mg) IV over 1 hour. The first 10% should be administered in 1 minute.
Heart attack: For patients weighing > 67 kg, 15 mg iv, followed by 50 mg over the next half an hour, and then 35 mg over the next 1 hour. The total dose of 100 mg may also be administered over 3 hours.

How should Alteplase be taken?

It comes as a solution for injection, to be injected by a healthcare provider into the vein.

What are the warnings and precautions for Alteplase?

• It may lead to serious bleeding, contact your doctor immediately.

Caution should be exercised in children, elderly, pregnant women, and patients with kidney disease.

Monitor for intracranial bleeding and blood pressure in acute stroke.

What are the side effects of Alteplase?

  Potentially Fatal: Bleeding in the brain.
   Heart : Heart failure, abnormal heart rhythm and heart arrest.
   Central Nervous System : Cerebral edema (increased fluid content in the brain).
  Miscellaneous: Allergic reactions, nausea, vomiting, low blood pressure and fever.

What are the other precautions for Alteplase?

Caution needed when administered with other drugs such as heparin and aspirin.

What are the storage conditions for Alteplase?

Injection: Store it at room temperature (<30C) or under refrigeration.




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raju0311, India

My younger brother was admitted Ashirwad Hospital Ghatkopar Mumbai on 5th January 2015 with cardiac problem and was stable after first aid was given to him. We were told that the patient requires an anticoagulant injection and was administered injection Alteplase was I V with in few seconds he went into cardiac failure instead of improving his condition in fact worsened his heart stopped and no other life saving support was able to revive him was declared dead very very dangerous drug. This happened in the facts can be confirmed by the hospital.

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