About Careers Internship MedBlog Contact us
Medindia LOGIN REGISTER
Advertisement

New Silver-based Chemotherapy Drug Kills Cancer Cells

Font : A-A+

Highlights:
  • Novel chemotherapy drug that can kill cancer cells effectively has been developed.
  • It is based on silver(I) thiocyanate 4-methoxyphenyl phosphine complex.
  • First generation silver(I) phosphines are known for their promising anticancer activity.

New Silver-based Chemotherapy Drug Kills Cancer Cells

Silver-based anti-cancer drugs based on silver thiocyanate phosphine complex have been developed and tested in rats and in human cancer cells in the laboratory by recent research in South Africa.

The most promising silver thiocyanate phosphine complex among these, called UJ3 for short, has been successfully tested in rats and in human cancer cells in the laboratory.

Advertisement


The research team shows that UJ3 is more effective against human esophageal cancer cells than chemotherapy drugs currently in use today.

"The UJ3 complex is as effective as the industry-standard drug Cisplatin in killing cancer cells in laboratory tests done on human breast cancer and melanoma, a very dangerous form of skin cancer, as well. However, UJ3 requires a 10 times lower dose to kill cancer cells. It also focuses more narrowly on cancer cells, so that far fewer healthy cells are killed," ," says Professor Marianne Cronjé, Head of the Department of Biochemistry at the University of Johannesburg.
Advertisement

Chemotherapy with less side-effects
The new drug, UJ3, is much less toxic than current chemotherapy drugs and requires a much lower dose.

According to Professor Reinout Meijboom, Head of the Department of Chemistry at the University of Johannesburg, rat studies have shown up to 3 grams of UJ3 can be tolerated per 1 kilogram of bodyweight which makes it as toxic as Vitamin C.

If UJ3 becomes a chemotherapy drug in future, there will be lower dosage, lesser toxicity, and more impact on cancer cells. Thus, this will reduce treatment side-effects.

Hope for side-effect free cancer treatment
UJ3 appears to target the mitochondria, resulting in programmed cell death to kill cancer cells - a process called apoptosis. When a cancer cell dies by apoptosis, the result is a neat and tidy process where the dead cell's remains are "recycled", not contaminating healthy cells around them, and not inducing inflammation.

Certain existing chemotherapy drugs are designed to induce apoptosis, rather than "septic" cell death which is called necrosis, for this reason.

Cancer cells grow much bigger and faster, and make copies of themselves much faster, than healthy cells do. In this way they create cancerous tumors. To do this, they need far more energy than healthy cells do.

UJ3 targets this need for energy, by shutting down the "powerhouses" of a cancer cell, the mitochondria. The complex then causes the release of the "executioner" protein, an enzyme called caspase-3, which goes to work to dismantle the cell's command center and structural supports, cutting it up for recycling in the last stages of apoptosis.

See microscope images of human esophageal cancer cells treated with the UJ3 complex.

Unusual compounds for novel cancer treatment
Since UJ3 complex and the others in the family are based on silver, the starter materials for synthesizing the complex are far more economical than a number of industry-standard chemotherapy drugs based on platinum.

"These complexes can be synthesized with standard laboratory equipment, which shows good potential for large scale manufacture. The family of silver thiocyanate phosphine compounds is very large. We were very fortunate to test UJ3, with is unusually 'flat' chemical structure, early on in our exploration of this chemical family for cancer treatment," says Prof Meijboom.

References :
  1. Zelinda Engelbrecht, Reinout Meijboom, Marianne J. Cronje. The ability of silver(I) thiocyanate 4-methoxyphenyl phosphine to induce apoptotic cell death in esophageal cancer cells is correlated to mitochondrial perturbations, BioMetals http://dx.doi.org/10.1007/s10534-017-0051-9


Source: Medindia

Citations   close

Please use one of the following formats to cite this article in your essay, paper or report:

  • APA

    Chrisy Ngilneii. (2018, March 26). New Silver-based Chemotherapy Drug Kills Cancer Cells. Medindia. Retrieved on Sep 25, 2022 from https://www.medindia.net/news/healthwatch/new-silver-based-chemotherapy-drug-kills-cancer-cells-178193-1.htm.

  • MLA

    Chrisy Ngilneii. "New Silver-based Chemotherapy Drug Kills Cancer Cells". Medindia. Sep 25, 2022. <https://www.medindia.net/news/healthwatch/new-silver-based-chemotherapy-drug-kills-cancer-cells-178193-1.htm>.

  • Chicago

    Chrisy Ngilneii. "New Silver-based Chemotherapy Drug Kills Cancer Cells". Medindia. https://www.medindia.net/news/healthwatch/new-silver-based-chemotherapy-drug-kills-cancer-cells-178193-1.htm. (accessed Sep 25, 2022).

  • Harvard

    Chrisy Ngilneii. 2021. New Silver-based Chemotherapy Drug Kills Cancer Cells. Medindia, viewed Sep 25, 2022, https://www.medindia.net/news/healthwatch/new-silver-based-chemotherapy-drug-kills-cancer-cells-178193-1.htm.

Advertisement

Advertisement
News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
What's New on Medindia
Test Your Knowledge About Chromosomes?
Eating During Sunlight Hours Minimizes Mood Vulnerabilities
Know More About the Digestive System
View all
Recommended Reading
News Archive
Date
Category
Advertisement
News Category

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Drug Toxicity Cancer and Homeopathy Parkinsons Disease Surgical Treatment Colorectal Cancer Chronic Lymphocytic Leukemia Hodgkins Lymphoma Non-Hodgkins Lymphoma Chemotherapy Chemotherapy Drugs Signature Drug Toxicity 

Most Popular on Medindia

Turmeric Powder - Health Benefits, Uses & Side Effects Blood Donation - Recipients Diaphragmatic Hernia How to Reduce School Bag Weight - Simple Tips Daily Calorie Requirements Drug - Food Interactions Post-Nasal Drip Noscaphene (Noscapine) A-Z Drug Brands in India Find a Hospital
This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use
×

New Silver-based Chemotherapy Drug Kills Cancer Cells Personalised Printable Document (PDF)

Please complete this form and we'll send you a personalised information that is requested

You may use this for your own reference or forward it to your friends.

Please use the information prudently. If you are not a medical doctor please remember to consult your healthcare provider as this information is not a substitute for professional advice.

Name *

Email Address *

Country *

Areas of Interests