Ademetionine is also is called as S-adenosylmethionine.
Ademetionine is used for treating chronic liver disease such as intrahepatic cholestasis, a condition related to reduced bile flow resulting in accumulation. It is also used to treat mood disorders such as depression, osteoarthritis, and muscle pain or fibromyalgia.
Ademetionine is contraindicated in patients with bipolar depression because of reports of increased anxiety and mania.
It should also not be used in patients allergic to the drug.
Oral: 400-1600 mg per day
IM/IV: 200-400 mg/day
Oral: 200 mg thrice daily
IV: 400 mg/day
Liver Disease, Alcohol Related
Oral: 1200-1600 mg per day; should not be administered for more than 2 years
IV: 200-2000 mg/day for 15-30 days
IM: 200 mg/day for 30 days
Oral: 800 mg twice a day
800 mg per day
Ademetionine tablets should be swallowed whole.
For better absorption of ademetionine and complete therapeutic effect, ademetionine tablets should not be taken with meals.
Caution is advised in patients with kidney disease.
Its use should be avoided in pregnancy especially in the first trimester; should be used only on the advice of a health care provider.
It should also be avoided during breastfeeding.
Gastrointestinal disorders: Vomiting, gas, constipation, diarrhea, loss of appetite, dry mouth
Nervous system disorders: Headache, insomnia, dizziness, nervousness
Serotonin syndrome: Symptoms include confusion, anxiety, tremors, diarrhea, high blood pressure and seizures
Others: Sweating, skin rashes, allergic reaction which could include anaphylactic reaction
Ademetionine should be used under the supervision of a physician.
Folate and vitamin b12 deficiencies may decrease ademetionine levels; therefore patients at risk of these deficiencies should routinely check their vitamin B12 and folic acid level while taking ademetionine.
Ademetionine should not be used in children and should be stopped at least two weeks before surgery.
Ammonia levels should be monitored in patients with liver disease taking the medication.
Ademetionine can precipitate serotonin syndrome when administered with antidepressant drugs like fluoxetine, sertraline and clomipramine, monoamine oxidase inhibitors like phenelzine and tranylcypromine, and supplements like St.John's wort.
It should not be used in patients taking antidiabetes medication since it cause a severe reduction in blood sugar levels.
Store at temperatures not exceeding 30°C.
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