Pallavi Singh
Written & Compiled by Pharmacist Pallavi Singh, M. Pharmacy (Pharmacy Practice)
Dr. Simi Paknikar
Medically Reviewed by Dr. Simi Paknikar, MD
Last Updated on Oct 12, 2017
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General Information on Ademetionine

Generic Name : Ademetionine

Pronunciation : Ade-met-ion-ine

Latest prescription information about Ademetionine. Learn how to pronounce the drug's name, its indications, dosage, how to take, when to take, when not to take, side effects, special precautions, its storage instructions and warnings if any when taken during pregnancy. Also listed are the International and Indian trade name(s) of the drug and its price list.
Therapeutic Classification : Anti- Inflammatory Agents

Trade Names/Brand Names of Ademetionine

India : 

Overview of Ademetionine

Ademetionine is also is called as S-adenosylmethionine.

Why is Ademetionine Prescribed? (Indications)

Ademetionine is used for treating chronic liver disease such as intrahepatic cholestasis, a condition related to reduced bile flow resulting in accumulation. It is also used to treat mood disorders such as depression, osteoarthritis, and muscle pain or fibromyalgia.  

When should Ademetionine not to be taken? (Contraindications)

• Ademetionine is contraindicated in patients with bipolar depression because of reports of increased anxiety and mania.
• It should also not be used in patients allergic to the drug.

What is the dosage of Ademetionine?

Depression
• Oral: 400-1600 mg per day
• IM/IV: 200-400 mg/day

Osteoarthritis
• Oral: 200 mg thrice daily
• IV: 400 mg/day

Liver Disease, Alcohol Related
• Oral: 1200-1600 mg per day; should not be administered for more than 2 years
• IV: 200-2000 mg/day for 15-30 days
• IM: 200 mg/day for 30 days

Intrahepatic Cholestasis
• Oral: 800 mg twice a day

Fibromyalgia
• 800 mg per day

How should Ademetionine be taken?

• Ademetionine tablets should be swallowed whole.
• For better absorption of ademetionine and complete therapeutic effect, ademetionine tablets should not be taken with meals.

What are the warnings and precautions for Ademetionine?

• Caution is advised in patients with kidney disease.
• Its use should be avoided in pregnancy especially in the first trimester; should be used only on the advice of a health care provider.
• It should also be avoided during breastfeeding.

What are the side effects of Ademetionine?

•  Gastrointestinal disorders: Vomiting, gas, constipation, diarrhea, loss of appetite, dry mouth
•  Nervous system disorders: Headache, insomnia, dizziness, nervousness
•  Serotonin syndrome: Symptoms include confusion, anxiety, tremors, diarrhea, high blood pressure and seizures
•  Others: Sweating, skin rashes, allergic reaction which could include anaphylactic reaction

What are the other precautions for Ademetionine?

• Ademetionine should be used under the supervision of a physician.
• Folate and vitamin b12 deficiencies may decrease ademetionine levels; therefore patients at risk of these deficiencies should routinely check their vitamin B12 and folic acid level while taking ademetionine.
• Ademetionine should not be used in children and should be stopped at least two weeks before surgery.
• Ammonia levels should be monitored in patients with liver disease taking the medication.

What are the Drug Interactions of Ademetionine?

• Ademetionine can precipitate serotonin syndrome when administered with antidepressant drugs like fluoxetine, sertraline and clomipramine, monoamine oxidase inhibitors like phenelzine and tranylcypromine, and supplements like St.John's wort.
• It should not be used in patients taking antidiabetes medication since it cause a severe reduction in blood sugar levels.

What are the storage conditions for Ademetionine?

• Store at temperatures not exceeding 30°C.

Last Updated : July 2018

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