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Pitofenone - Indications, Dosage, Side Effects and Precautions

Last Updated on May 03, 2018
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General Information on Pitofenone

Generic Name : Pitofenone
Latest prescription information about Pitofenone. Learn its indications, dosage, how to take, when to take, when not to take, side effects, special precautions, warnings and its storage instructions . Also listed are the International and Indian trade name(s) of the drug and its price list.
Therapeutic Classification : Antispasmodics
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Overview of Pitofenone

• Pitofenone is an antispasmodic drug that is used to relieve pain and spasms of smooth muscles of the stomach, intestines, urinary tract, biliary tract, and uterus.

Why is Pitofenone Prescribed? (Indications)

Pitofenone is an antispasmodic (spasmolytic) drug that is used to relieve pain and spasms of smooth muscles. It works by suppressing the muscle spasms and then relaxing the muscles of the stomach, intestine or urinary bladder.
Pitofenone is also used for the treatment of back pain, sprains, and strains.

Pitofenone is used in combination along with fenpiverinium bromide, and metamizole sodium. The drug is currently sold in Eastern Europe and India under various trade names.

The combined preparation possesses strong analgesic, spasmolytic, cholinolytic and anti-inflammatory effects on the smooth muscles predominantly of the gastrointestinal and urogenital tract. Indications are strong pain in gastric or intestinal colic, kidney and gallstones, and for painful menstruation.

Pitofenone hydrochloride present in the combination exerts papaverin-like spasmolytic effect on the vascular and extra-vascular smooth muscles of the stomach, intestines, urinary tract, biliary tract, and uterus.

As of 2005, any combined preparation containing a spasmolytic drug like pitofenone and metamizole must include a boxed warning that the use of the drug is not recommended in children and adolescents under the age of 18 years. Also, it can be used only for short-term treatment of severe pains caused by smooth muscles’ spasm where other therapy shows ineffectiveness.  

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When should Pitofenone not be taken? (Contraindications)

• Pitofenone is contraindicated in patients hypersensitive to the drug or any of the other drugs in the combined preparation.

What is the dosage of Pitofenone?

• The recommended dose of the pitofenone is 50 to 75 mg tablet
• Dosage is based on the condition.
• Pitofenone is part of an injection which contains 500 mg metamizole sodium, 0.02 mg fenpiverine bromide and 2 mg pitofenone hydrochloride in 1 ml of the solution.

How should Pitofenone be taken?

The tablet should be taken by mouth with food and the injection should be given directly into the muscle by a healthcare provider.

What are the warnings and precautions for Pitofenone?

• Consult your doctor if you are using any analgesic or antirheumatic drug
• Consult your doctor if you have bronchial asthma or chronic respiratory infections
• Use caution if you have allergies, pre-existing diseases, and current health conditions like pregnancy or any upcoming surgery

What are the side effects of Pitofenone?

  Central nervous system: Dizziness and headache
  Skin: Skin rashes, itching
  Gastrointestinal: Dry mouth

What are the other precautions for Pitofenone?

• Avoid excess dose

What are the Drug Interactions of Pitofenone?

• Not known.

What are the storage conditions for Pitofenone?

• Pitofenone should be stored at room temperature.

Last Updated : 5/3/2018



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