Pallavi Singh
Written & Compiled by Pharmacist Pallavi Singh, M. Pharmacy (Pharmacy Practice)
Dr. Simi Paknikar
Medically Reviewed by Dr. Simi Paknikar, MD
Last Updated on Nov 08, 2017
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General Information on Metamizole

Generic Name : Metamizole

Pronunciation : Met-ami-zole

Latest prescription information about Metamizole. Learn how to pronounce the drug's name, its indications, dosage, how to take, when to take, when not to take, side effects, special precautions, warnings and its storage instructions . Also listed are the Indian trade name(s) of the drug and its price list.
Therapeutic Classification : Analgesic And Antipyretic Agent

Trade Names/Brand Names of Metamizole

Analgin, Baralgan -M

Overview of Metamizole

Metamizole is also known as dipyrone.
It has analgesic properties.
Metamizole is used for the treatment of postoperative pain and other painful conditions.

Why is Metamizole Prescribed? (Indications)

Metamizole is a painkiller used for the treatment of fever, headache, toothache, postoperative pain and other painful conditions.
It belongs to the group non-steroidal anti-inflammatory drugs (NSAIDs).
It has been banned in several countries including the United States and India due to its ability to reduce white blood cell counts and cause a condition called agranulocytosis.  

When should Metamizole not to be taken? (Contraindications)

Metamizole should not be used by patients with:

Allergy to the drug or other NSAIDs
Liver or kidney problems
Low blood counts
Stomach ulcer
Acute intermittent porphyria
Glucose-6-phosphate dehydrogenase deficiency
Asthma, optic neuritis, myasthenia gravis, glaucoma, enlarged prostate

It should also not be used during pregnancy, breastfeeding and in children and the elderly.

What is the dosage of Metamizole?

The recommended oral adult dose for metamizole is 500 mg 3-4 times up to a maximum dose of 4000 mg/day.
The injection is administered in a dose of 250-500 mg three times a day up to a maximum daily dose of 2g in adults into a muscle or a vein.

How should Metamizole be taken?

The tablet should be administered orally with food.
The intravenous dose should be administered through a slow infusion into a vein.

What are the warnings and precautions for Metamizole?

The higher dose levels may be dangerous for patients.
Doctors should monitor the blood count at the time of treatment.
Patients with low blood pressure should not use this drug. The intravenous drug should not be given rapidly since it can cause a fall in blood pressure.

What are the side effects of Metamizole?

  Blood: Reduced white blood cell counts (agranulocytosis), reduced red blood cell counts due to reduced production of the cells (aplastic anemia). May trigger acute porphyria
  Skin: Severe skin reactions like toxic epidermal necrolysis
  Kidney: Kidney damage
  Cardiovascular system: Low blood pressure
  Others: Allergic reaction which may include a rash, low blood pressure, and breathing difficulty

What are the other precautions for Metamizole?

Patients allergic to soy or peanut should not take the medication.
It should not be taken with alcohol.

What are the Drug Interactions of Metamizole?

Metamizole may increase the effect of anticoagulants and antiplatelet drugs.
It may interact with anti-hypertensive drugs causing low blood pressure.
It may alter the effects of penicillin, sulfonamides, corticosteroids and anti-diabetes drugs.
It may reduce the effect of cyclosporine.
Sedatives and hypnotics may increase the blood levels of metamizole.

What are the storage conditions for Metamizole?

Metamizole should be stored below 25C.

Last Updated : 11/8/2017

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