• Metamizole is also known as dipyrone.
• It has analgesic properties.
• Metamizole is used for the treatment of postoperative pain and other painful conditions.
Metamizole is a painkiller used for the treatment of fever, headache, toothache, postoperative pain and other painful conditions.
It belongs to the group non-steroidal anti-inflammatory drugs (NSAIDs).
It has been banned in several countries including the United States and India due to its ability to reduce white blood cell counts and cause a condition called agranulocytosis.
Metamizole should not be used by patients with:
• Allergy to the drug or other NSAIDs
• Liver or kidney problems
• Low blood counts
• Stomach ulcer
• Acute intermittent porphyria
• Glucose-6-phosphate dehydrogenase deficiency
• Asthma, optic neuritis, myasthenia gravis, glaucoma, enlarged prostate
It should also not be used during pregnancy, breastfeeding and in children and the elderly.
• The recommended oral adult dose for metamizole is 500 mg 3-4 times up to a maximum dose of 4000 mg/day.
• The injection is administered in a dose of 250-500 mg three times a day up to a maximum daily dose of 2g in adults into a muscle or a vein.
• The tablet should be administered orally with food.
• The intravenous dose should be administered through a slow infusion into a vein.
• The higher dose levels may be dangerous for patients.
• Doctors should monitor the blood count at the time of treatment.
• Patients with low blood pressure should not use this drug. The intravenous drug should not be given rapidly since it can cause a fall in blood pressure.
• Blood: Reduced white blood cell counts (agranulocytosis), reduced red blood cell counts due to reduced production of the cells (aplastic anemia). May trigger acute porphyria
• Skin: Severe skin reactions like toxic epidermal necrolysis
• Kidney: Kidney damage
• Cardiovascular system: Low blood pressure
• Others: Allergic reaction which may include a rash, low blood pressure, and breathing difficulty
• Patients allergic to soy or peanut should not take the medication.
• It should not be taken with alcohol.
• Metamizole may increase the effect of anticoagulants
and antiplatelet drugs.
• It may interact with anti-hypertensive drugs causing low blood pressure.
• It may alter the effects of penicillin, sulfonamides, corticosteroids and anti-diabetes drugs.
• It may reduce the effect of cyclosporine.
• Sedatives and hypnotics may increase the blood levels of metamizole.
• Metamizole should be stored below 25°C.