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Pitofenone is an antispasmodic (spasmolytic) drug that is used to relieve pain and spasms of smooth muscles. It works by suppressing the muscle spasms and then relaxing the muscles of the stomach, intestine or urinary bladder.
Pitofenone is also used for the treatment of back pain, sprains, and strains.

Pitofenone is used in combination along with fenpiverinium bromide, and metamizole sodium. The drug is currently sold in Eastern Europe and India under various trade names.

The combined preparation possesses strong analgesic, spasmolytic, cholinolytic and anti-inflammatory effects on the smooth muscles predominantly of the gastrointestinal and urogenital tract. Indications are strong pain in gastric or intestinal colic, kidney and gallstones, and for painful menstruation.

Pitofenone hydrochloride present in the combination exerts papaverin-like spasmolytic effect on the vascular and extra-vascular smooth muscles of the stomach, intestines, urinary tract, biliary tract, and uterus.

As of 2005, any combined preparation containing a spasmolytic drug like pitofenone and metamizole must include a boxed warning that the use of the drug is not recommended in children and adolescents under the age of 18 years. Also, it can be used only for short-term treatment of severe pains caused by smooth muscles’ spasm where other therapy shows ineffectiveness.  

Drug information on Mefen Spas (75+3.99+0.04 (Pitofenone - Combination) from Oyster Labs Limited

Mefen Spas (75+3.99+0.04

Oyster Labs Limited
Generic : Pitofenone
75mg / 3.99mg / 0.04mg / 3ml
Combination of Generics : Pitofenone, Diclofenac Sodium, Fenpiverinium Bromide
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Side effects of Pitofenone

  Central nervous system: Dizziness and headache

  Skin: Skin rashes, itching

  Gastrointestinal: Dry mouth

When is Pitofenone not to be taken? (Contraindications)

• Pitofenone is contraindicated in patients hypersensitive to the drug or any of the other drugs in the combined preparation.


Disclaimer : The Price of the drugs indicated above may not match the actual price at which they are sold. Prices can change depending on many factors, including GST. These are only approximate indicative prices of the drug.
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