Phenazone, also called antipyrine, is used
Orally to reduce fever and pain in conditions like migraine.
As ear drops, as a pain reliever and a local anesthetic:
For the treatment of ear ache caused by an acute inflammation of the middle ear (acute otitis media) in a combination with other medications
Along with benzocaine before ear wax removal to facilitate the removal of the earwax, and after the removal to dry the external ear canal and relieve any discomfort
Phenazone is contraindicated in the following conditions:
Allergy to the drug
Glucose-6-phosphate dehydrogenase deficiency
Acute hepatic porphyria
Pregnancy and during breastfeeding
The ear drops should not be used in patients with a perforated ear drum or discharge from the ear
The recommended dose of phenazone is:
Oral: 1 g every 4 to 8 hourly; maximum of 4 g in a day
As ear drops: 3 to 4 drops into the external ear canal. It should be administered three times daily for 2 to 3 days to soften the ear wax. It can be used every 1-2 hourly for the treatment of earache as needed.
The external ear canal can be covered with a cotton plug moistened with the ear drops solution after putting the drops if the doctor advises the same.
If you do not feel better in two to three days with the medication, contact your doctor
Stop using the drug if you develop an allergic reaction. Phenazone should be used with caution in individuals allergic to other drugs or substances
Do not use phenazone in patients with blood count abnormalities
Caution should be taken in patients with upcoming surgery
Avoid touching the tip of the dropper to the ears, fingers or anywhere else to prevent contamination
Ear: Burning, redness, swelling, and pain in the ear, dizziness
Others: Allergic reactions that may include skin rash, itching, swelling of face, breakdown of red blood cells (hemolysis), porphyria
Do not use the drug if you are allergic to it
Inform your doctor if you are pregnant or breastfeeding, or planning a pregnancy before using the medication
The oral drug may reduce the effect of warfarin
Medications like phenytoin, carbamazepine, barbiturates, spironolactone and rifampin may reduce the effect of phenazone
Medications like cimetidine, disulfiram, propranolol, verapamil, diltiazem, amiodarone, oral contraceptives and ketoconazole may increase the blood level of phenazone
Keep out of reach of children.
Store at room temperature.
Discard the ear drops a few months after opening as advised by the manufacturer. Replace the cap of the dropper after use.
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