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Last Updated : 12/7/2017

General Information on Phenazone

Generic Name : Phenazone

Pronunciation : Phe-Na-zone

Latest prescription information about Phenazone. Learn how to pronounce the drug's name, its indications, dosage, how to take, when to take, when not to take, side effects, special precautions, its storage instructions and warnings if any when taken during pregnancy. Also listed are the International and Indian trade name(s) of the drug and its price list.
Therapeutic Classification : Analgesic And Antipyretic Agent

Trade Names/Brand Names of Phenazone

Other Name(s) of Phenazone


Overview of Phenazone

• Phenazone, also called antipyrine, is used orally for fever and painful conditions like migraine and as ear drops to treat ear ache.

Why is Phenazone Prescribed? (Indications)

Phenazone, also called antipyrine, is used

Orally to reduce fever and pain in conditions like migraine.
As ear drops, as a pain reliever and a local anesthetic:
For the treatment of ear ache caused by an acute inflammation of the middle ear (acute otitis media) in a combination with other medications
Along with benzocaine before ear wax removal to facilitate the removal of the earwax, and after the removal to dry the external ear canal and relieve any discomfort

When should Phenazone not to be taken? (Contraindications)

Phenazone is contraindicated in the following conditions:

• Allergy to the drug
• Glucose-6-phosphate dehydrogenase deficiency
• Acute hepatic porphyria
• Pregnancy and during breastfeeding
• Children
• The ear drops should not be used in patients with a perforated ear drum or discharge from the ear

What is the dosage of Phenazone?

• The recommended dose of phenazone is:

Oral: 1 g every 4 to 8 hourly; maximum of 4 g in a day
As ear drops: 3 to 4 drops into the external ear canal. It should be administered three times daily for 2 to 3 days to soften the ear wax. It can be used every 1-2 hourly for the treatment of earache as needed.

How should Phenazone be taken?

• The external ear canal can be covered with a cotton plug moistened with the ear drops solution after putting the drops if the doctor advises the same.

What are the warnings and precautions for Phenazone?

• If you do not feel better in two to three days with the medication, contact your doctor
• Stop using the drug if you develop an allergic reaction. Phenazone should be used with caution in individuals allergic to other drugs or substances
• Do not use phenazone in patients with blood count abnormalities
• Caution should be taken in patients with upcoming surgery
• Avoid touching the tip of the dropper to the ears, fingers or anywhere else to prevent contamination

What are the side effects of Phenazone?

•  Ear: Burning, redness, swelling, and pain in the ear, dizziness
•  Others: Allergic reactions that may include skin rash, itching, swelling of face, breakdown of red blood cells (hemolysis), porphyria

What are the other precautions for Phenazone?

• Do not use the drug if you are allergic to it
• Inform your doctor if you are pregnant or breastfeeding, or planning a pregnancy before using the medication

What are the Drug Interactions of Phenazone?

• The oral drug may reduce the effect of warfarin
• Medications like phenytoin, carbamazepine, barbiturates, spironolactone and rifampin may reduce the effect of phenazone
• Medications like cimetidine, disulfiram, propranolol, verapamil, diltiazem, amiodarone, oral contraceptives and ketoconazole may increase the blood level of phenazone

What are the storage conditions for Phenazone?

• Keep out of reach of children.
• Store at room temperature.
• Discard the ear drops a few months after opening as advised by the manufacturer. Replace the cap of the dropper after use.

Last Updated : 12/7/2017

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