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Neostigmine - Indications, Dosage, Side Effects and Precautions

Last Updated on August 11, 2022
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Information about Neostigmine

Generic Name : Neostigmine
Up-to-date prescription details regarding Neostigmine are provided here.
Pronunciation : NEE-oh-STIG-meen
Learn the correct pronunciation of the Neostigmine, understand it's uses, recommended dosages, its indications, how to take, when to take, when not to take, side effects, special precautions, warnings and its and its storage instructions.
You will also find a list of the medication's International and Indian brand or trade names, as well as its pricing information. For verification of the information presented on this page or for additional clarifications, it's advisable to consult your doctor.
ICD Code : Y51.1 | Therapeutic Classification : Cholinergic Agents

Trade Names/Brand Names of Neostigmine


Why is Neostigmine Prescribed? (Indications)

This medication is a cholinesterase inhibitor, prescribed for Myasthenia Gravis. It inhibits the chemicals, which brings non-communication between the nervous and the muscular system. Neostigmine enhances the muscular movements in case of Myasthenia Gravis condition.  

When should Neostigmine not be taken? (Contraindications)

It is not prescribed in patients with mechanical intestinal obstruction or urinary tract obstruction, peritonitis; known hypersensitivity.

What is the dosage of Neostigmine?

Oral/IV: The recommended dose is 15 mg to 375 mg per day in divided doses.

How should Neostigmine be taken?

It comes as a tablet to take by mouth, and solution for injection.

What are the warnings and precautions for Neostigmine?

• Caution should be exercised in patients with epilepsy, bronchial asthma, slow heart beat, recent heart attack, low blood pressure, over activity or irritability of the vagus nerve, increased level of thyroid hormone, recent intestinal or bladder surgery, kidney impairment, abnormal heart rhythm, peptic ulcer, during pregnancy and breastfeeding.

Inform the doctor if you experience symptoms like muscular weakness and respiratory paralysis. Clear difference need to be made between the symptoms caused due to excess dosage of anticholinesterase drugs and Myasthenia Gravis condition. Avoid excess dosage

What are the side effects of Neostigmine?

  Most Common: Increased salivation, sweating, nausea, vomiting, abdominal cramps and diarrhea.
  Central Nervous System: Dizziness, convulsions, loss of consciousness, drowsiness, headache, speech disorder and vision changes.
  Heart: Abnormal heart rhythm, circulatory arrest, fainting and low blood pressure.
  Respiratory: Difficulty in breathing, respiratory depression, respiratory arrest and asthma.
  Skin: Rash and hives.
  Gastrointestinal : Flatulence and increased peristalsis.
  Genitourinary: Increased urinary frequency.
  Musculoskeletal : Muscle cramps and joint pain.
  Miscellaneous: Excessive sweating, flushing and weakness.
  Potentially Fatal: Anaphylaxis.

What are the other precautions for Neostigmine?

Prior to the administration of neostigmine injection, atropine medication is injected in order to avoid allergic reactions.

What are the storage conditions for Neostigmine?

Store it at room temperature (15-30C). Protect from light. Do not freeze.
Last Updated : August 11, 2022

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