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Neostigmine is a cholinesterase inhibitor, prescribed for Myasthenia Gravis. It inhibits the chemicals, which brings non-communication between the nervous and the muscular system. Neostigmine enhances the muscular movements in case of Myasthenia Gravis condition.  

Drug information on Neostigmine (Neostigmine) from Piramal Healthcare


Piramal Healthcare
Generic : Neostigmine
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Medical Condition(s) for which Neostigmine may be prescribed

Side effects of Neostigmine

  Most Common: Increased salivation, sweating, nausea, vomiting, abdominal cramps and diarrhea.

  Central Nervous System: Dizziness, convulsions, loss of consciousness, drowsiness, headache, speech disorder and vision changes.

  Heart: Abnormal heart rhythm, circulatory arrest, fainting and low blood pressure.

  Respiratory: Difficulty in breathing, respiratory depression, respiratory arrest and asthma.

  Skin: Rash and hives.

  Gastrointestinal : Flatulence and increased peristalsis.

  Genitourinary: Increased urinary frequency.

  Musculoskeletal : Muscle cramps and joint pain.

  Miscellaneous: Excessive sweating, flushing and weakness.

  Potentially Fatal: Anaphylaxis.

Dosage & When it is to be taken (Indications)

Oral/IV: The recommended dose is 15 mg to 375 mg per day in divided doses.

How to use Neostigmine?

It comes as a tablet to take by mouth, and solution for injection.

When is Neostigmine not to be taken? (Contraindications)

It is not prescribed in patients with mechanical intestinal obstruction or urinary tract obstruction, peritonitis; known hypersensitivity.

Warnings and Precautions for Neostigmine

Caution should be exercised in patients with epilepsy, bronchial asthma, slow heart beat, recent heart attack, low blood pressure, over activity or irritability of the vagus nerve, increased level of thyroid hormone, recent intestinal or bladder surgery, kidney impairment, abnormal heart rhythm, peptic ulcer, during pregnancy and breastfeeding.

• Inform the doctor if you experience symptoms like muscular weakness and respiratory paralysis. Clear difference need to be made between the symptoms caused due to excess dosage of anticholinesterase drugs and Myasthenia Gravis condition. Avoid excess dosage

Other Precautions for Neostigmine

Prior to the administration of neostigmine injection, atropine medication is injected in order to avoid allergic reactions.

Storage Conditions for Neostigmine

Store it at room temperature (15-30°C). Protect from light. Do not freeze.

Disclaimer : The Price of the drugs indicated above may not match the actual price at which they are sold. Prices can change depending on many factors, including GST. These are only approximate indicative prices of the drug.
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