About Careers MedBlog Contact us
Medindia LOGIN REGISTER
Advertisement

New Cancer Drug Shrinks Tumors With Few Side Effects

by VR Sreeraman on April 9, 2011 at 10:15 PM
Font : A-A+

 New Cancer Drug Shrinks Tumors With Few Side Effects

Scientists at the University of Michigan Comprehensive Cancer Center showed in animal studies that new cancer drug compounds they developed shrank tumors, with few side effects.

The study, done in two mouse models of human cancer, looked at two compounds designed to activate a protein that kills cancer cells.

Advertisement

The protein, p53, is inactivated in a significant number of human cancers. In some cases, it is because another protein, MDM2, binds to p53 and blocks its tumor suppressor function.

This allows the tumor to grow unchecked. The new compounds block MDM2 from binding to p53, consequently activating p53.

"For the first time, we showed that activation of p53 by our highly potent and optimized MDM2 inhibitors can achieve complete tumor regression in a mouse model of human cancer," said lead study author Shaomeng Wang.
Advertisement

Many traditional cancer drugs also activate p53 but they do so by causing DNA damage in both tumor cells and normal cells, causing side effects.

These new MDM2 inhibitors activate p53 while avoiding the DNA damage common with other drugs. In this study researchers showed that these new drugs shrank tumors without significant side effects.

Because p53 is involved in all types of human cancer, the new drug has potential to be used in multiple types of cancer.

Further, the researchers also identified certain markers in tumors that predict which ones will be particularly sensitive to the MDM2 inhibitor, which would allow physicians to target the drug only to patients most likely to benefit.

The study was presented at the American Association for Cancer Research 102nd annual meeting.

Source: ANI
Advertisement

Advertisement
News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
What's New on Medindia
World Disability Day 2022 - The Role of Innovative Transformation
Diet and Oral Health: The Sugary Connection May Become Sour
World AIDS Day 2022 - Equalize!
View all
Recommended Reading
News Archive
Date
Category
News Category

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Drug Toxicity Cancer and Homeopathy Signature Drug Toxicity Cancer Facts Cancer Tattoos A Body Art Oncology Drug Delivery Systems Common Lifestyle Habits that Cause Diseases Health Benefits of Dandelion Plant Immune Checkpoint Inhibitors for Cancer Treatment 

Most Popular on Medindia

Accident and Trauma Care Sanatogen Drug - Food Interactions Blood - Sugar Chart Loram (2 mg) (Lorazepam) Find a Doctor Daily Calorie Requirements Noscaphene (Noscapine) Turmeric Powder - Health Benefits, Uses & Side Effects Blood Donation - Recipients
open close
ASK A DOCTOR ONLINE

×

New Cancer Drug Shrinks Tumors With Few Side Effects Personalised Printable Document (PDF)

Please complete this form and we'll send you a personalised information that is requested

You may use this for your own reference or forward it to your friends.

Please use the information prudently. If you are not a medical doctor please remember to consult your healthcare provider as this information is not a substitute for professional advice.

Name *

Email Address *

Country *

Areas of Interests