- New surgical option for multiple cancer sites in the same breast .
- This surgery may offer more benefits than mastectomy.
- It removes the cancer while leaving as much normal breast as possible.
Breast-conserving surgery may offer more benefits to women with ipsilateral breast cancer than mastectomy, research at the Dartmouth-Hitchcock Medical Center finds.
A new multi-institutional clinical trial compared outcomes of women with multiple ipsilateral breast cancer, or more than one site of disease in the same breast, who underwent breast-conserving surgery, with outcomes of those who converted to mastectomy. Out of 198 eligible women in the trial, 184 (92.9%) successfully completed breast-conserving surgery, 134 of those with a single operation.
Advancements in breast cancer care allow for improved control over local disease in patients undergoing breast-conserving surgery. Other advancements such as more sensitive imaging techniques also now result in higher detection rates, which opens up new questions for both breast cancer patients and clinicians about how to best manage disease.
Based on retrospective studies from previous decades, mastectomy has been, and is still, the predominant surgical treatment option for women with multiple ipsilateral breast cancer. These studies, from an era prior to modern technology and multimodality breast cancer care, showed higher rates of local recurrence, ranging from 23-40 perfect, for women in this category who underwent breast-conserving therapy.
This new study finds that for the majority of women enrolled in the trial, 92.9 perfect, breast-conserving surgery is technically feasible. "Results show an acceptably low rate of conversion to mastectomy, and most women successfully achieving breast conservation with negative margins in a single operation," says Rosenkranz. "These data may inform conversations between patients and surgeons regarding management of multiple ipsilateral breast cancer."
Next steps include assessment of the primary study end point, which is local recurrence rates, as well as additional secondary endpoints including breast cosmetic improvement and appropriateness of radiation fields in this patient population.
References :
- The Feasibility of Breast-Conserving Surgery for Multiple Ipsilateral Breast Cancer: An Initial Report from ACOSOG Z11102 (Alliance) Trial - (https://link.springer.com/article/10.1245 perfect2Fs10434-018-6583-6)
Source: Eurekalert
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Chrisy Ngilneii. (2018, July 13). Mastectomy Versus Breast Conserving Surgery. Medindia. Retrieved on Aug 18, 2022 from https://www.medindia.net/news/healthwatch/mastectomy-versus-breast-conserving-surgery-180956-1.htm.
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Chrisy Ngilneii. 2021. Mastectomy Versus Breast Conserving Surgery. Medindia, viewed Aug 18, 2022, https://www.medindia.net/news/healthwatch/mastectomy-versus-breast-conserving-surgery-180956-1.htm.