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Cancer treatment can now be improved by identifying DNA repair genes according to a new study.
High-Fat Diet may Up Inflammation and Cancer
High-fat diet can increase nitric oxide levels, which increases inflammation in the tumor microenvironment.
High-fat diet can increase nitric oxide levels, which increases inflammation in the tumor microenvironment.
TOP INSIGHT
New study sheds light on DNA repair genes by cancer cells, how cancer cells react to treatment (chemotherapy and radiotherapy), and the ways by which cancer can become resistant to targeted treatments.
DNA Repair in Cancer
The team specifically pinpointed two previously unidentified proteins in the DNA repair process — SETD1A and BOD1L, that help in modifying other DNA-bound proteins (called histones).It was found that removing these two proteins changes how DNA is repaired, and makes cancer cells more sensitive to radiotherapy. Moreover, the loss of SETD1A and BOD1L makes cancer cells resistant to certain anti-cancer drugs called PARP inhibitors.
“This is the first time that these genes have been directly linked to DNA repair in cancer. This research has the potential to change how cancer patients are identified for treatment and also how they become resistant to different drugs, which will improve treatment efficiency as well as patient outcomes,” says lead author Martin Higgs.
New Platform Could Advance Ovarian Cancer Detection
The machine learning method developed by researchers efficiently analyzes spectral signatures of carbon nanotubes to detect biomarkers of ovarian cancer.
The machine learning method developed by researchers efficiently analyzes spectral signatures of carbon nanotubes to detect biomarkers of ovarian cancer.
Source-Medindia
Drugs Showing Promise in Cancer Trials Down Scarring in Scleroderma
Drugs that have shown promise in cancer clinical trials significantly reduce scarring in the cells of patients with scleroderma.
Drugs that have shown promise in cancer clinical trials significantly reduce scarring in the cells of patients with scleroderma.
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