In mice with inflammatory arthritis, noninvasive daily ultrasound stimulation of the spleen resulted in significantly less joint swelling compared to arthritic mice that were not treated, said researchers at the University of Minnesota, in collaboration with researchers at Medtronic. The research is a first step to developing new treatment options for more than a million people in the United States who currently suffer from rheumatoid arthritis.
The research is currently published in Nature Communications and has resulted in a University of Minnesota-led preliminary human clinical trial.
Ultrasound
Ultrasound scan or sonogram uses sound waves to obtain images of the internal organs. Ultrasound scan is used during pregnancy and to examine breast, abdomen, renal and thyroid.
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‘Noninvasive ultrasound stimulation of spleen could lead to new treatments for inflammatory arthritis.’
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"What we found in our mouse study is that we could actually 'turn down' the inflammatory response with daily ultrasound stimulation of the spleen from outside the body," said Daniel Zachs, the first author of the study and a biomedical engineering researcher in the University of Minnesota's College of Science and Engineering. "We're hopeful that this type of noninvasive treatment could someday supplement current treatments for people with rheumatoid arthritis."
Inflammatory arthritis is an autoimmune disease, which means that the body's immune system attacks healthy tissue in addition to germs, viruses and other foreign substances. This reaction can cause pain, stiffness, and joint damage. Current treatments usually include medicines that have a wide variety of side effects.
![Quiz on Arthritis]( "Quiz on Arthritis")
Do you know that there are more than 100 types of arthritis? If you think that only old people suffer from arthritis, take this intriguing quiz to get your facts on arthritis.
Researchers involved in this new study induced inflammatory arthritis in laboratory mice and then targeted the spleen with ultrasound stimulation for seven days following the injection. Some mice were treated only after the arthritis was evident on the third day. The mice that received the ultrasound treatment had significantly less joint swelling than arthritic mice that did not receive ultrasound stimulation.
"Using noninvasive ultrasound stimulation of the spleen to treat a progressive disease like inflammatory arthritis seemed like a far-fetched idea," said Hubert Lim, Ph.D., a senior author of the study and a University of Minnesota biomedical engineering associate professor in the College of Science and Engineering and the Medical School. "We were pleasantly surprised with our results and how a separate study, independently performed by GE Research and The Feinstein Institute for Medical Research published in the same issue of Nature Communications, showed findings that were consistent with our research."
In addition to focusing on reducing inflammation, the researchers also studied the specific type of white blood cells that were required for reducing inflammation. By analyzing gene expression and deleting specific types of white blood cells, the researchers found that white blood cells called T cells and B cells were both involved in reducing the severity of arthritis.
"Rheumatoid arthritis can be a devasting disease if not treated aggressively," said Bryce Binstadt, M.D., Ph.D., a senior author of the study and an associate professor of Pediatrics in the Division of Pediatric Rheumatology in the University of Minnesota Medical School. "The idea that we can improve arthritis treatment by using ultrasound rather than additional medications is exciting. This research shows the progress we can make when doctors and engineers come together to solve problems."
Source: Eurekalert
Quiz on Arthritis
Do you know that there are more than 100 types of arthritis? If you think that only old people suffer from arthritis, take this intriguing quiz to get your facts on arthritis.
Advertisement
Researchers involved in this new study induced inflammatory arthritis in laboratory mice and then targeted the spleen with ultrasound stimulation for seven days following the injection. Some mice were treated only after the arthritis was evident on the third day. The mice that received the ultrasound treatment had significantly less joint swelling than arthritic mice that did not receive ultrasound stimulation.
"Using noninvasive ultrasound stimulation of the spleen to treat a progressive disease like inflammatory arthritis seemed like a far-fetched idea," said Hubert Lim, Ph.D., a senior author of the study and a University of Minnesota biomedical engineering associate professor in the College of Science and Engineering and the Medical School. "We were pleasantly surprised with our results and how a separate study, independently performed by GE Research and The Feinstein Institute for Medical Research published in the same issue of Nature Communications, showed findings that were consistent with our research."
In addition to focusing on reducing inflammation, the researchers also studied the specific type of white blood cells that were required for reducing inflammation. By analyzing gene expression and deleting specific types of white blood cells, the researchers found that white blood cells called T cells and B cells were both involved in reducing the severity of arthritis.
"Rheumatoid arthritis can be a devasting disease if not treated aggressively," said Bryce Binstadt, M.D., Ph.D., a senior author of the study and an associate professor of Pediatrics in the Division of Pediatric Rheumatology in the University of Minnesota Medical School. "The idea that we can improve arthritis treatment by using ultrasound rather than additional medications is exciting. This research shows the progress we can make when doctors and engineers come together to solve problems."
Source: Eurekalert
New Ultrasound Approach for Thrombosis Prevention
A new approach based on ultrasonic registration of blood coagulation in its early stages has been developed by scientists.
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