Potential Biomarker for Treatments of Breast and Pancreatic Cancers Discovered

by Colleen Fleiss on  March 19, 2019 at 12:02 AM Cancer News
RSS Email Print This Page Comment bookmark
Font : A-A+

The deubiquitinating enzyme USP15 was found to have a key role in future treatment of breast and pancreatic cancers, stated a team at the George Washington University (GW) Cancer Center. Their findings were published in Nature Communications.
Potential Biomarker for Treatments of Breast and Pancreatic Cancers Discovered
Potential Biomarker for Treatments of Breast and Pancreatic Cancers Discovered

"With this study, we validate the role of USP15 in maintaining genome stability and tumor suppression and inform novel treatments for breast cancer," said Huadong Pei, PhD, assistant professor of biochemistry and molecular medicine at the GW School of Medicine and Health Sciences and senior author on the study. "With consistent research and progress of current studies, we will gain a stronger understanding and a more comprehensive view of USP15 functions in cancer and their role in future treatment strategies."

Studies have shown that cancer-associated USP15 mutations increase poly ADP ribose polymerase (PARP) inhibitor sensitivity in cancer cells.

PARP inhibitors are a new class of pharmacological inhibitors developed for multiple purposes, but chiefly for the treatment of cancer. They have garnered a great deal of attention for their potential in the management of patients with BRCA mutations.

Pei and his research team found that USP15 regulates homologous recombination -- one of the major pathways to repair DNA damage affecting broth strands of the double helix -- and cancer cell response to PARP inhibitors.

USP15 is part of a group of deubiquitinating enzymes, responsible for removing ubiquitin chains from proteins and other molecules, which play important roles in maintaining genome stability. Based on their research, Pei and his team believe USP15 may function similarly to the USP4 enzyme, which was found to play a role in DNA repair by Pei's group four years ago.

"USP15 is a potential biomarker for treatments of pancreatic cancer, as well as breast and ovarian cancers," explained Yihan Peng, a PhD student in Pei's lab and the first author on the study.

As a next step, researchers will use patient-derived tissue graft models to examine the impact of the USP15 enzyme on radiochemotherapy response. Additionally, they will perform high-throughput screening for USP15 inhibitors.

Source: Eurekalert

Post a Comment

Comments should be on the topic and should not be abusive. The editorial team reserves the right to review and moderate the comments posted on the site.
Notify me when reply is posted
I agree to the terms and conditions
Advertisement

Recommended Reading

More News on:

Pancreatic Cancer Mastitis Breasts - Structures and Types Pancreatitis Breast Lumps Breast Lumps-Screening Breast Enhancement Oil Pancreas Transplantation 

News A - Z

A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

News Search

Medindia Newsletters

Subscribe to our Free Newsletters!

Terms & Conditions and Privacy Policy.

Find a Doctor

Stay Connected

  • Available on the Android Market
  • Available on the App Store

News Category

News Archive