Changes in potassium channels involved in pain detection are more sensitive to temperature and touch stimuli on faces and cause headaches without body pain behaviors. This makes the defective potassium channel with such cell-specific roles, a target for migraine treatment research.
Defective potassium channels involved in pain detection can increase the chance of developing a headache and could be implicated in migraines, according to research in mice published in eNeuro.
A type of potassium channel called TRESK is thought to control the excitability of peripheral sensory neurons that detect pain, heat, cold, and touch. Even though these channels are found throughout the neurons sensing both body and facial pain, channel mutations are linked only with headaches and not body pain.
These results indicate that TRESK channels have cell-specific roles and are responsible for regulating pain in facial sensory neurons, making them a target for migraine treatment research.