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Trifluoperazine - Indications, Dosage, Side Effects and Precautions

Written by Anushta Chandrapalan, M.Sc  | Medically Checked by S. Hemamalini, B. Pharm
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Information about Trifluoperazine

Generic Name : Trifluoperazine
Up-to-date prescription details regarding Trifluoperazine are provided here.
Pronunciation : trye floo oh per' a zeen
Learn the correct pronunciation of the Trifluoperazine, understand it's uses, recommended dosages, its indications, how to take, when to take, when not to take, side effects, special precautions, warnings and its and its storage instructions.
You will also find a list of the medication's International and Indian brand or trade names, as well as its pricing information. For verification of the information presented on this page or for additional clarifications, it's advisable to consult your doctor.
ICD Code : Y49.3 | Therapeutic Classification : Psychotherapeutics

Trade Names/Brand Names of Trifluoperazine

India : 


International : 


Other Name(s) of Trifluoperazine

Eskazinyl, Eskazine, Jatroneural, Modalina, Stelazine, Terfluzine, Trifluoperaz, Triftazin.

Why is Trifluoperazine Prescribed? (Indications)

This medication is a tranquilizer, prescribed for schizophrenia (emotional and mental conditions). It works by decreasing abnormal excitement in the brain.


When should Trifluoperazine not be taken? (Contraindications)

Contraindicated in patients with bone marrow depression, liver damage, coma and hypersensitivity.

What is the dosage of Trifluoperazine?

Schizophrenia- PO: Usual starting dosage is 2 mg to 5 mg two times per day.
Non-psychotic Anxiety - Usual dosage is 1 or 2 mg twice daily.

How should Trifluoperazine be taken?

It comes as a tablet to take by mouth, with food.

What are the warnings and precautions for Trifluoperazine?

• Caution should be exercised in patients with history of heart problems, blood problems, neuroleptic malignant syndrome (NMS), Parkinson disease, glaucoma, high or low blood pressure, prostate problems, breast cancer, increased eye pressure, seizures, chest pain, heart disease, alcohol abuse, depression, any allergy, who are taking other medications, during pregnancy and breastfeeding.

• Avoid taking this medication 2 days before and 1 day after the myelogram examination (x-ray examination of the spine).

• It may cause drowsiness, dizziness, fainting or blurred vision, do not drive a car or operate machinery and get up slowly from bed while taking this medication.

• Avoid becoming over heated; otherwise it may cause heat stroke.

• Patient may develop with involuntary movements, NMS (Neuroleptic Malignant Syndrome) with the following symptoms: stiff muscles, confusion, abnormal thinking, fast or irregular heartbeat. If it is so consult with your doctor.

• Avoid contact with people who have infections.

• Avoid exposure to sunlight; otherwise it may cause sunburn easily.

• Perform tests for phenylketonuria (PKU) and pregnancy regularly while taking this medication.

What are the side effects of Trifluoperazine?

   Most Common : Drowsiness, dizziness, skin reactions, rash, dry mouth, sleeplessness, absence of menstrual periods, fatigue, muscular weakness, loss of appetite, spontaneous secretion of milk, blurred vision and neuromuscular (extrapyramidal) reactions.
   Central Nervous System : Headache, extreme tiredness, weakness, muscle stiffness, confusion, agitation and jitteriness.
   Gastrointestinal : Nausea and constipation.
   Skin : Sweating and yellowing of the skin.
   Genitourinary : Impotence and breast enlargement/tenderness in male.
   Allergic Reactions : Blisters, hives, itching, difficulty in breathing or swallowing, swelling of the eyes, face, mouth, lips, tongue, throat, arms, hands, feet, ankles or lower legs.
   Eye : Vision loss.
   Miscellaneous : Fever, flu-like symptoms, sore throat, chills and other signs of infection.

What are the other precautions for Trifluoperazine?

Avoid alcohol consumption.

What are the storage conditions for Trifluoperazine?

Store it at room temperature (15° and 30°C).

Schedule : H
Prescription drugs - Drugs to be sold only under the prescription of a Registered Medical Practitioner.
Last Updated : August 11, 2022
Learn more about Trifluoperazine's interaction with Food, Herbs and Alcohol

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Ramendra123, India

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