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Sulbutiamine - Indications, Dosage, Side Effects and Precautions

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Information about Sulbutiamine

Generic Name : Sulbutiamine
Up-to-date prescription details regarding Sulbutiamine are provided here.

Understand it's uses, recommended dosages, its indications, how to take, when to take, when not to take, side effects, special precautions, warnings and its and its storage instructions.
You will also find a list of the medication's International and Indian brand or trade names, as well as its pricing information. For verification of the information presented on this page or for additional clarifications, it's advisable to consult your doctor.


Therapeutic Classification : Dietary Supplements

Trade Names/Brand Names of Sulbutiamine

India :

International :


Arcalion, Neuro flow, Surmenalit, Enerion, Megastene

Overview of Sulbutiamine

• Sulbutiamine is a synthetic derivative of vitamin B1 or thiamine.
• It readily crosses blood-brain barrier than thiamine and increases the levels of thiamine and its esters in the brain.

Why is Sulbutiamine Prescribed? (Indications)

Sulbutiamine is prescribed for the treatment of asthenia, a condition of severe weakness which is mainly of central nervous system (CNS) or brain origin rather than neuromuscular origin.

It is used to improve brain function where it acts by boosting memory and reducing psycho-behavioral inhibition, and in some cases to enhance erectile dysfunction.

It has been used to memory and cognitive performance in Alzheimer’s disease and schizophrenia.

Sulbutiamine is used to improve the asthenia and the quality of life in patients suffering from chronic illnesses such as high blood pressure, diabetes and heart disease.

When should Sulbutiamine not be taken? (Contraindications)

Sulbutiamine is not recommended in:

Allergy to the drug
• Patients under 18 years of age
• Pregnant women, who should not take sulbutiamine because of the lack of safety data in fetus

What is the dosage of Sulbutiamine?

• The recommended minimal adult oral dose is 200mg daily.
• The adult dose can be increased to 400mg to 600mg daily when there are no side effects within 4-5 days.
• The maximum usual adult dose should not exceed above 600mg per day.
• However, in case of severe asthenic syndrome the daily dose of 600mg - 800 mg of sulbutiamine can be prescribed either as a single or in divided doses.

How should Sulbutiamine be taken?

• Sulbutiamine comes as a tablet and should be taken by mouth. It is taken with food.
• The tablets should be taken with sufficient quantity of water and should not be crushed, chewed or broken to avoid the release of the medicine at a time.

What are the warnings and precautions for Sulbutiamine?

• The nearest emergency center has to be contacted in case of serious allergic reaction such as swelling, hives, difficulty in breathing and swallowing.

• Breastfeeding should be avoided or a physician should be consulted before breastfeeding women take sulbutiamine.

What are the side effects of Sulbutiamine?

Central Nervous System: Headache, loss of appetite, irritation, mood swings and agitation in elderly
Respiratory: Difficulty in breathing and chest tightness
Skin: Dermatitis, epidermolysis, itching of the skin and lupus symptoms
Others: Kidney failure, increased uric acid levels, nausea and conjunctivitis

What are the other precautions for Sulbutiamine?

• Sulbutiamine is not suitable for all patients. Therefore, it should not be taken without proper physician advice.
• Patients who wish to conceive should consult their doctor before taking sulbutiamine.

What are the Drug Interactions of Sulbutiamine?

• Not known.
• However, sulbutiamine should be taken with prescription drugs, over-the-counter drugs or herbal supplements only on medical advice.

What are the storage conditions for Sulbutiamine?

• Store at a room temperature below 30° C. Keep away from excess heat and moisture.
• Keep out of reach of children.
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