Written & Compiled by Anushta Chandrapalan, M.Sc  | Medically Reviewed by The Medindia Medical Review Team on 6/17/2021 11:42:06 PM
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General Information on Spironolactone

Generic Name : Spironolactone

Pronunciation : speer on oh lak' tone

Latest prescription information about Spironolactone. Learn how to pronounce the drug's name, its indications, dosage, how to take, when to take, when not to take, side effects, special precautions, warnings and its storage instructions . Also listed are the International and Indian trade name(s) of the drug and its price list.
ICD Code : Y54.5 | Therapeutic Classification : Diuretics

Why is Spironolactone Prescribed? (Indications)

This medication is a potassium-sparing diuretic, prescribed for hyperaldosteronism, low potassium levels, and for edema (fluid retention) caused by various conditions. It works by blocking the hormone aldosterone.

When should Spironolactone not to be taken? (Contraindications)

Contraindicated in patients with anuria (absence of urination), and significant impairment of kidney function.

What is the dosage of Spironolactone?

Adult- PO- The recommended dose range is 50 to 400mg/day for 3 to 4 weeks.

How should Spironolactone be taken?

It comes as a tablet to take by mouth, with food.

What are the warnings and precautions for Spironolactone?

• Caution should be exercised in patients with history of changes in blood minerals, kidney, liver, or heart disease, diabetes or high level of urea or nitrogen in blood, any allergy, who are taking other medications, elderly, children, during pregnancy and breastfeeding.

• It may cause dizziness or drowsiness, do not drive a car or operate machinery while taking this medication.

What are the side effects of Spironolactone?

   Gastrointestinal : Gastric bleeding, ulceration, stomach inflammation, diarrhea, cramping, nausea and vomiting.
   Genitourinary : Breast enlargement in male, absence of menstrual period, painful erection, irregular periods, breast cancer, kidney impairment and postmenopausal bleeding.
   Blood : Decrease in blood counts.
   Hypersensitivity : Fever, hives, shock, inflammation of veins and skin lesions.
   Metabolic : Elevated blood potassium level.
   Central Nervous system : Mental confusion, incoordination, headache, drowsiness and lethargy.
   Liver : Liver damage.

What are the other precautions for Spironolactone?

Avoid excess dosage.

What are the storage conditions for Spironolactone?

Store it at room temperature (25°C).

Schedule : H

Prescription drugs - Drugs to be sold only under the prescription of a Registered Medical Practitioner.

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ramdass, India

nice ...i like your way out...it gives a clear information....can u tell whether this drug has any such specification about its dose,either to take in morning or night?

SueJackson, United Kingdom

My 87 year old mother was prescribed this (along with her usual water tablet) for fluid retention to both lungs and legs. The medication reduced the symptoms dramatically but unforunateley the side effects left her very confused with short term memory loss. The doctor has now taken her off the tablet and her mental state much improved but after just a week we have noticed her legs starting to swell again. is there an alternative, sililar product that does not have the same side effect?

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