Pallavi Singh
Written & Compiled by Pharmacist Pallavi Singh, M. Pharmacy (Pharmacy Practice)
Dr. Simi Paknikar
Medically Reviewed by Dr. Simi Paknikar, MD
Last Updated on Jan 18, 2018
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General Information on Mazindol

Generic Name : Mazindol

Pronunciation : MA-zin-doll

Latest prescription information about Mazindol. Learn how to pronounce the drug's name, its indications, dosage, how to take, when to take, when not to take, side effects, special precautions, warnings and its storage instructions . Also listed are the International and Indian trade name(s) of the drug and its price list.
Therapeutic Classification : Appetite Suppressants

Trade Names/Brand Names of Mazindol

India : 

International : 

Sanorex, Mazanor, Mazindol

Overview of Mazindol

Mazindol has been used for the treatment of obesity.

Why is Mazindol Prescribed? (Indications)

Mazindol, a drug used for the treatment of obesity along with lifestyle changes, is not currently available in the United States or the European Union for this purpose.
It decreases the appetite and thereby the weight of a patient with a high body mass index.

It has received an orphan drug status in the European Union for the treatment of narcolepsy, a condition that results in an irresistible desire to sleep. 

When should Mazindol not to be taken? (Contraindications)

Mazindol is contraindicated in the following conditions:

Allergy to the drug
Narrow-angle glaucoma
Severe liver or kidney disease or hypertension
Heart or brain disease
Pulmonary artery hypertension
Psychological conditions like anorexia nervosa, depression, agitation, history of drug abuse or alcoholism (since it is habit forming)
Children, pregnancy, breastfeeding

What is the dosage of Mazindol?

For obesity, mazindol is started on a low dose of 0,5 to 1 mg, and can be increased on a weekly basis up to a maximum of 3 mg per day in divided doses.
It is administered for a maximum of 12 weeks.

How should Mazindol be taken?

Mazindol drugs should be taken with food in divided doses.

What are the warnings and precautions for Mazindol?

Avoid sudden withdrawal if taken for a prolonged duration since it may cause withdrawal symptoms.

What are the side effects of Mazindol?

  Gastrointestinal: Diarrhea, constipation, dryness of mouth, taste disturbance
  Nervous system: Headache, tremor, nervousness, anxiety, agitation, seizures, hallucinations, dizziness, depression, psychosis, vertigo, insomnia, abnormal sensations
  Cardiovascular system: High blood pressure, palpitations, chest pain, pulmonary artery hypertension, flushing
  Others: Asthenia, allergic reaction, sexual dysfunction, menstrual problems in women, sweating, blurred vision

What are the other precautions for Mazindol?

Do not take the drug while driving and operating machinery as it can cause dizziness, blurred vision and may mask extreme tiredness.

What are the Drug Interactions of Mazindol?

Mazindol may have an additive effect with other weight loss drugs that act on the brain.
Severe high blood pressure may occur in patients taking monoamine oxidase inhibitors (MAO inhibitors).
Therefore, a gap of at least 14 days should be maintained between the two drugs.
The intake of mazindol by patients taking lithium may result in lithium toxicity.
The dose of diabetes medications may have to be altered in patients taking mazindol.
Antidepressant drugs may reduce the effects of mazindol.

What are the storage conditions for Mazindol?

Mazindol should be stored in a well-closed container, below 30C.

Last Updated : 1/18/2018

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