• Mazindol has been used for the treatment of obesity.
Mazindol, a drug used for the treatment of obesity along with lifestyle changes, is not currently available in the United States or the European Union for this purpose.
It decreases the appetite and thereby the weight of a patient with a high body mass index.
It has received an orphan drug status in the European Union for the treatment of narcolepsy, a condition that results in an irresistible desire to sleep.
Mazindol is contraindicated in the following conditions:
• Allergy to the drug
• Narrow-angle glaucoma
• Severe liver or kidney disease or hypertension
• Heart or brain disease
• Pulmonary artery hypertension
• Psychological conditions like anorexia nervosa, depression, agitation, history of drug abuse or alcoholism (since it is habit forming)
• Children, pregnancy, breastfeeding
• For obesity, mazindol is started on a low dose of 0,5 to 1 mg, and can be increased on a weekly basis up to a maximum of 3 mg per day in divided doses.
• It is administered for a maximum of 12 weeks.
• Mazindol drugs should be taken with food in divided doses.
• Avoid sudden withdrawal if taken for a prolonged duration since it may cause withdrawal symptoms.
• Gastrointestinal: Diarrhea, constipation, dryness of mouth, taste disturbance
• Nervous system: Headache, tremor, nervousness, anxiety, agitation, seizures, hallucinations, dizziness, depression, psychosis, vertigo, insomnia, abnormal sensations
• Cardiovascular system: High blood pressure, palpitations, chest pain, pulmonary artery hypertension, flushing
• Others: Asthenia, allergic reaction, sexual dysfunction, menstrual problems in women, sweating, blurred vision
• Do not take the drug while driving and operating machinery as it can cause dizziness, blurred vision and may mask extreme tiredness.
• Mazindol may have an additive effect with other weight loss drugs that act on the brain.
• Severe high blood pressure may occur in patients taking monoamine oxidase inhibitors (MAO inhibitors).
• Therefore, a gap of at least 14 days should be maintained between the two drugs.
• The intake of mazindol by patients taking lithium may result in lithium toxicity.
• The dose of diabetes medications may have to be altered in patients taking mazindol.
• Antidepressant drugs may reduce the effects of mazindol.
• Mazindol should be stored in a well-closed container, below 30°C.
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