Lusutrombopag is used to treat thrombocytopenia, a condition of abnormally low platelet counts in adult patients with severe liver dysfunction who are scheduled to undergo a medical or dental procedure.
Low platelet counts can lead to uncontrollable bleeding during surgery. This may delay the procedure or even stop treatment because of the risk it can cause the patient. Lusutrombopag helps in increasing the platelet count and thereby reduces the need for platelet transfusion before a surgery.
Lusutrombopag is a thrombopoietin receptor agonist which works by stimulating the thrombopoietin receptors which enhance the production of the platelets in the blood.
Lusutrombopag should not be used in patients with-
Allergic to lusutrombopag
Pregnant and breastfeeding
Children below 18 years of age should not be given lusutrombopag tablets as the safety and effectiveness of lusutrombopag have not been studied in these groups.
Lusutrombopag should not be used only to increase the platelet count in patients with liver disease if there are no requirements for a medical procedure.
The recommended adult dose of lusutrombopag is 3 mg once a day for up to 7 days.
If a dose of lusutrombopag is missed, the missed dose must be taken as soon as the patient remembers and the next dose on the following day as per the prescribed schedule.
Lusutrombopag should be taken as a single daily dose for one week and should not be taken for more than the duration prescribed.
Lusutrombopag is available in tablet form and should be taken by mouth with or without food.
Start taking lusutrombopag tablets at least 8 to 14 days before a medical or dental procedure is planned.
Patients must undergo their medical procedure within 2 to 8 days after the last dose of lusutrombopag.
Never chew, break or crush the tablet contents.
Swallow the lusutrombopag tablet as a whole with a sufficient quantity of water.
Patients should be advised to perform a platelet count test before a medical procedure or just two days before a surgery is planned. This is required to check for sufficient platelet counts so as to reduce the risk to the patient during surgery.
Patients taking lusutrombopag are at an increased risk of blood clot formation; therefore patients must be carefully observed for the symptoms and signs of portal vein thrombosis, a condition of narrowing or blockage of the blood vessel that brings blood to the liver.
In case of clotting events, patients should be managed appropriately with proper medical care under the supervision of a medical specialist.
Lusutrombopag can harm patients who have a history of blood clots or reduced blood flow to the liver. So, it must only be used if lusutrombopag can benefit the patient against the risk it causes the patient.
Breastfeeding should not be done during the treatment with lusutrombopag and should be restrained for at least 28 days after the last dose of lusutrombopag.
The most common side effect of lusutrombopag is a headache.
Patients can also experience worsening of existing liver damage due to blood clots that could occur during the treatment with lusutrombopag.
These blood clots obstruct or make the blood vessel narrow resulting in an inadequate blood flow to the liver that could further lead to portal hypertension (increased blood pressure in the blood vessels of the liver).
Patients must consult a doctor immediately when side effects caused by lusutrombopag tablets are disturbing or troublesome.
Do not take an extra dose as it may result in severe or life-threatening side effects.
Never recommend lusutrombopag to another person who has the same symptoms or signs without a doctors approval.
Avoid taking drugs that cause a reduction in platelet count. Otherwise, it may worsen the condition of existing thrombocytopenia.
Some drugs that cause decreased platelet count and should be avoided are-
Sulfonamide group of antibiotics
Nonsteroidal anti-inflammatory drugs (to treat pain and swelling)
Gold (to treat arthritis)
Drugs to treat cancer
Store lusutrombopag tablets at room temperature between 20°C and 25°C.
Protect the tablets from excess light and moisture.
Keep the tablets away from the reach of children.
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