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Letrozole - Indications, Dosage, Side Effects and Precautions

Written & Compiled by Anushta Chandrapalan, M.Sc  | Medically Reviewed by The Medindia Medical Review Team
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Information about Letrozole

Generic Name : Letrozole
Pronunciation : LET-roe-zole
Latest prescription information about Letrozole. Learn how to pronounce the drug's name, its indications, dosage, how to take, when to take, when not to take, side effects, special precautions, warnings and its storage instructions . Also listed are the International and Indian trade name(s) of the drug and its price list.
ICD Code : Y43.3 | Therapeutic Classification : Chemotherapy
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Trade Names/Brand Names of Letrozole

India : 

International : 

Femara
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Why is Letrozole Prescribed? (Indications)

This medication is an aromatase inhibitor, prescribed for breast cancer either alone or in combination with other medications. It kills cancer cells. 

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When should Letrozole not be taken? (Contraindications)

Contraindicated in women who have experienced with premenopause, and for children; hypersensitivity.

What is the dosage of Letrozole?

The recommended dose is 2.5mg/day, orally, administered after chemotherapy for breast cancer.

How should Letrozole be taken?

It comes as a tablet to take by mouth, with or without food.

What are the warnings and precautions for Letrozole?

• Inform your doctor about severe kidney, liver problem, bone diseases.

• It may make you drowsy. Do not drive a car or operate machinery until knowing its effect.

• It is only for women who have experienced menopause and cannot become pregnant. Inform your doctor about your pregnancy and lactation.

What are the side effects of Letrozole?

  Heart: Hypertension, chest pain, coronary heart disease, paralysis, strokes, heart attack, fluid accumulation in the lungs, vein inflammation, mini stroke and blood clot in veins.
  Central Nervous System: Weakness, headache, dizziness, fatigue, sleeplessness, drowsiness, anxiety and depression.
  Skin: Hot flushes, increased sweating, night sweats, rash, hair loss and itching.
  Eye and ENT: Blurred vision.
  Gastrointestinal: Nausea, constipation, diarrhea, vomiting, abdominal pain and loss of appetite.
  Genitourinary: Breast pain, urinary tract infection, kidney disorder, vaginal bleeding and vaginal dryness.
  Liver: Increased liver enzymes level.
  Metabolic: High level of cholesterol in blood, increased weight and high calcium in blood.
  Musculoskeletal: Joint pain, bone pain, back pain, limb pain, inflammation of joints, muscle pain, fracture and inflammation due to fracture.
  Respiratory: Difficulty in breathing, cough and chest wall pain.
  Miscellaneous: Swelling of leg, infections/infestations, influenza, pain and pleural effusion.

What are the other precautions for Letrozole?

Monitor bone mineral density regularly.

What are the storage conditions for Letrozole?

Store at 25�C. Store it in air tight container and keep away from children.




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