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Imipramine - Indications, Dosage, Side Effects and Precautions

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Information about Imipramine

Generic Name : Imipramine
Up-to-date prescription details regarding Imipramine are provided here.

Pronunciation : im ip' ra meen

Learn the correct pronunciation of the Imipramine, understand it's uses, recommended dosages, its indications, how to take, when to take, when not to take, side effects, special precautions, warnings and its and its storage instructions.
You will also find a list of the medication's International and Indian brand or trade names, as well as its pricing information. For verification of the information presented on this page or for additional clarifications, it's advisable to consult your doctor.


ICD Code : Y49.0 Therapeutic Classification : Psychotherapeutics

Trade Names/Brand Names of Imipramine

India :

International :


Tofranil

Why is Imipramine Prescribed? (Indications)

This medication is an antidepressant, prescribed for depression. It is also used to treat bedwetting in children. It increases the amount of certain natural substances in the brain.

When should Imipramine not be taken? (Contraindications)

Contraindicated in patients with recovery period after a heart attack, who are taking MAOIs, linezolid or intravenous methylene blue and hypersensitivity.

What is the dosage of Imipramine?

Adult: PO- Initial dose: 100 mg per day given in 3 to 4 divided doses.
Pediatric Dose for Primary Nocturnal Enuresis: Initial dose: 25 mg per day orally 1 hour before bedtime.

How should Imipramine be taken?

It comes as a tablet and capsule to take by mouth, with or without food.

What are the warnings and precautions for Imipramine?

• Caution should be exercised in patients with history of increased eye pressure, prostate enlargement, difficulty in urinating, seizures, overactive thyroid, liver, kidney or heart disease, any allergy, who are taking other medications, during pregnancy and breast feeding.

• It may cause drowsiness or dizziness, do not drive a car or operate machinery while taking this medication.

• Avoid alcohol consumption and smoking while taking this medication.

• Avoid exposure to sunlight; otherwise it may cause skin sensitivity.

• Patient may develop Serotonin Syndrome with the following symptoms: increased heart rate, shivering, sweating, dilated pupils.

What are the side effects of Imipramine?

Heart - Low/high blood pressure, fast heart rate, palpitations, heart attack, abnormal heart rhythm, heart block, ECG changes, heart failure and stroke.
Psychiatric - Confusion, hallucinations, disorientation, anxiety, restlessness, agitation, sleeplessness, abnormal dreams and irritable mood.
Central Nervous System - Numbness, tingling, incoordination, tremors, seizures, alterations in EEG patterns and ringing in the ear.
Eye - Blurred vision, visual disturbances and dilatation of pupil.
Allergic Reactions - Skin rash, hives, itching, photosensitization, swelling in the face and tongue and fever.
Blood - Bone marrow depression.
Gastrointestinal - Nausea, vomiting, dry mouth, loss of appetite, constipation, stomach upset, diarrhea, intestinal obstruction, mouth ulcer, abdominal cramps and black tongue.
Genitourinary - Breast enlargement in the male, spontaneous milk secretion in the female, increased or decreased sexual drive, impotence, testicular swelling, elevation or depression of blood sugar levels, urinary retention and dilation of the urinary tract.
Other - Jaundice and hair loss.

What are the other precautions for Imipramine?

Avoid excess dosage.

What are the storage conditions for Imipramine?

Store it at room temperature (20° to 25°C), and in an airtight container. Keep away from children.

Schedule : H
Prescription drugs - Drugs to be sold only under the prescription of a Registered Medical Practitioner.
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