Written & Compiled by Anushta Chandrapalan, M.Sc  | Medically Reviewed by The Medindia Medical Review Team on 8/6/2018 5:18:01 AM
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General Information on Imipramine

Generic Name : Imipramine

Pronunciation : im ip' ra meen

Latest prescription information about Imipramine. Learn how to pronounce the drug's name, its indications, dosage, how to take, when to take, when not to take, side effects, special precautions, warnings and its storage instructions . Also listed are the International and Indian trade name(s) of the drug and its price list.
ICD Code : Y49.0 | Therapeutic Classification : Psychotherapeutics

Why is Imipramine Prescribed? (Indications)

This medication is an antidepressant, prescribed for depression. It is also used to treat bedwetting in children. It increases the amount of certain natural substances in the brain.

When should Imipramine not to be taken? (Contraindications)

Contraindicated in patients with recovery period after a heart attack, who are taking MAOIs, linezolid or intravenous methylene blue and hypersensitivity.

What is the dosage of Imipramine?

Adult: PO- Initial dose: 100 mg per day given in 3 to 4 divided doses.
Pediatric Dose for Primary Nocturnal Enuresis: Initial dose: 25 mg per day orally 1 hour before bedtime.

How should Imipramine be taken?

It comes as a tablet and capsule to take by mouth, with or without food.

What are the warnings and precautions for Imipramine?

• Caution should be exercised in patients with history of increased eye pressure, prostate enlargement, difficulty in urinating, seizures, overactive thyroid, liver, kidney or heart disease, any allergy, who are taking other medications, during pregnancy and breast feeding.

• It may cause drowsiness or dizziness, do not drive a car or operate machinery while taking this medication.

• Avoid alcohol consumption and smoking while taking this medication.

• Avoid exposure to sunlight; otherwise it may cause skin sensitivity.

• Patient may develop Serotonin Syndrome with the following symptoms: increased heart rate, shivering, sweating, dilated pupils.

What are the side effects of Imipramine?

•   Heart : Low/high blood pressure, fast heart rate, palpitations, heart attack, abnormal heart rhythm, heart block, ECG changes, heart failure and stroke.
•   Psychiatric : Confusion, hallucinations, disorientation, anxiety, restlessness, agitation, sleeplessness, abnormal dreams and irritable mood.
•   Central Nervous System : Numbness, tingling, incoordination, tremors, seizures, alterations in EEG patterns and ringing in the ear.
•   Eye : Blurred vision, visual disturbances and dilatation of pupil.
•   Allergic Reactions : Skin rash, hives, itching, photosensitization, swelling in the face and tongue and fever.
•   Blood : Bone marrow depression.
•   Gastrointestinal : Nausea, vomiting, dry mouth, loss of appetite, constipation, stomach upset, diarrhea, intestinal obstruction, mouth ulcer, abdominal cramps and black tongue.
•   Genitourinary : Breast enlargement in the male, spontaneous milk secretion in the female, increased or decreased sexual drive, impotence, testicular swelling, elevation or depression of blood sugar levels, urinary retention and dilation of the urinary tract.
•   Other : Jaundice and hair loss.

What are the other precautions for Imipramine?

Avoid excess dosage.

What are the storage conditions for Imipramine?

Store it at room temperature (20° to 25°C), and in an airtight container. Keep away from children.

Schedule : H

Prescription drugs - Drugs to be sold only under the prescription of a Registered Medical Practitioner.

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my mother whose age is 70 years old is having severe urination. too frequently she passes urin. can she take depsonil 25 mg one every day?? She is known asthematic patient. pl.advice.

ussein gazi, India

Taking sodium valporate 3 times a day each time 200 and amixide 25mg a day, feeling anxiety and panic and mood remains off sometimes, feeling 80 percent ok


As I experienced, Imipramine is one of the best antidepressents.

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