- 1. Dabigatran - (https://medlineplus.gov/druginfo/meds/a610024.html )
- 2. Higher Risk of Bleeding with Dabigatran in Atrial Fibrillation - (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6608584/ )
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This medication is an anticoagulant (blood thinner), prescribed for preventing strokes or serious blood clots in risky patients. It is also used in COVID-19 patients to prevent blood clot formation.
Dabigatran should not be used in patients with
Allergy to Dabigatran or any of the ingredients
Patients with active pathological bleeding including bleeding veins, bleeding from peptic ulcer, recent surgeries.
For patients with creatinine clearance (CrCl) > 30 mL/min- The recommended dose is 150 mg taken orally, twice daily.
For patients with CrCl 15-30 mL/min- The recommended dose is 75 mg twice daily.
It comes as a capsule to take by mouth, with or without food.
• Caution should be exercised in patients with history of stomach bleeding, kidney disease, who are taking other medications, any allergy, elderly, children, during pregnancy and breastfeeding.
• Avoid abrupt withdrawal; otherwise it may lead to increased risk of stroke.
• Patient may develop with increased risk of bleeding; if it is so consult with your doctor.
• Most common: Bleeding in a critical area or organ, indigestion, nausea, upper abdominal pain, gastrointestinal bleeding and diarrhea.
• Hypersensitivity: Hives, rash and itching.
Caution is required in patients with history of
• Stomach bleeding, ulcer
• Kidney disease
• Elderly, children,
• Pregnancy and breastfeeding
Dabigatran can interact with the following drugs in various extents:
• Rifampicin
• Dronedarone
• Ketoconazole
Store it at room temperature (25°C), and in an airtight container. Protect from moisture.
A: Do not stop taking dabigatran without first consulting your doctor. Stopping dabigatran abruptly may increase your risk of a clot or stroke(1✔ ✔Trusted Source
Dabigatran
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A: Dabigatran belongs to the group of anticoagulants known as direct thrombin inhibitors. It works by preventing the formation of blood clots in the body(1✔ ✔Trusted Source
Dabigatran
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A: Dabigatran was linked to an increased risk of gastrointestinal bleeding but a decreased risk of intracranial hemorrhage(2✔ ✔Trusted Source
Higher Risk of Bleeding with Dabigatran in Atrial Fibrillation
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A: Dabigatran is a medication that can be taken orally as pellets or capsules. Take dabigatran pellets with soft food or apple juice. Mixing the pellets with milk or foods containing milk products is not recommended(1✔ ✔Trusted Source
Dabigatran
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A: The capsules of dabigatran can be taken with or without food. To ensure that your child receives the full dose, give dabigatran pellets before meals. Sprinkle the entire packet of pellets on soft food to prepare a dose of dabigatran pellets(1✔ ✔Trusted Source
Dabigatran
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Paradaxa medicine is expensive. 110mg costs above Rs 700 in India. A monthly dose costs over 4000. Any alternate brands for same active ingredient?