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Ceftriaxone - Indications, Dosage, Side Effects and Precautions

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Information about Ceftriaxone

Generic Name : Ceftriaxone
Pronunciation : SEF-trye-AX-one
Latest prescription information about Ceftriaxone. Learn how to pronounce the drug's name, its indications, dosage, how to take, when to take, when not to take, side effects, special precautions, warnings and its storage instructions . Also listed are the International and Indian trade name(s) of the drug and its price list.
ICD Code : Y40.1 | Therapeutic Classification : Antibiotics
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Trade Names/Brand Names of Ceftriaxone

India : 

More...

International : 

Rocephin
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Overview of Ceftriaxone

Ceftriaxone is an antibiotic, used for the treatment of various infections.

Why is Ceftriaxone Prescribed? (Indications)

Ceftriaxone is indicated for:
• Lower Respiratory Tract Infections
• Skin infections
• Urinary Tract Infections
• Pelvic Inflammatory Disease –infections related to the female genital tract Bacterial Septicemia-infection in the blood
• Bone and Joint Infections
• Meningitis
• Surgical Prophylaxis –To prevent infections during surgery  
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When should Ceftriaxone not be taken? (Contraindications)

Ceftriaxone should not be used by patients with allergy to ceftriaxone or other cephalosporin class antibacterials, penicillins, or other beta-lactam antibacterials

What is the dosage of Ceftriaxone?

Middle ear infection: Children - IM A single dose of 50 mg/kg (max, 1 gram) is recommended.
Meningitis in children: Children - IV: Recommended initial dose is 100 mg/kg (max, 4 gram), followed by 100 mg/kg/day (max, 4 gram/day) for 7 to 14 days.
Skin or Skin Structure Infections: Children - IV/IM: Recommended daily dosage is 50 to 75 mg/kg once a day or in equally divided doses twice daily (max, 2 gram/day).
Surgical Prophylaxis: Adults - IV: 1 gram as a single dose 30 min to 2 hours before surgery.
Uncomplicated Gonococcal Infections: Adults - IM: 250 mg as single dose.
Miscellaneous Infections: Adults - IV: Usual adult daily dosage is 1 to 2 g once a day or in equally divided doses twice daily, depending on the type and severity of infection (max, 4 gram/day).
Children- IV: Recommended daily dose is 50 to 75 mg/kg IV once a day or in divided doses every 12 h (max, 2 gram/day). IV/IM: Recommended daily dose is 50 to 75 mg/kg IV/IM in divided doses every 12 h (max, 2 gram/day).
Acute Bacterial Otitis Media Persistent/Treatment Failure: Children - IM/IV 50 mg/kg/ IM or IV (not to exceed 1 gram) daily for 3 days.
Pelvic Inflammatory Disease (mild to moderate): Adults - IM 250 mg given IM as a single dose with doxycycline 100 mg orally twice daily for 14 days, with or without metronidazole 500 mg orally twice daily for 14 days.
Uncomplicated Gonococcal Infections: Adults - IM 125 mg given IM as a single dose.
Typhoid:Adult- IV: 4gm/day for 2 days, followed by 2g/day. Child- 75mg/day for 2 days.

How should Ceftriaxone be taken?

It should be given by intravenous route only over around 30 minutes.
The usual Adult Dose is 1 g to 2 g once a day or in equally divided doses twice a day.
The total dose should not exceed 4 grams.
Patients with liver and kidney problems should not receive more than 2 grams per day of ceftriaxone.

What are the warnings and precautions for Ceftriaxone?

• Ceftriaxone may cause allergic reactions. Cross-allergies may occur in up to 10% of patients with a history of penicillin allergy. Discontinue the drug in this case.
• The drug may cause Clostridium difficile-associated diarrhea
• Avoid excess dosage

What are the side effects of Ceftriaxone?

  Central Nervous System: Dizziness, Headache.
  Gastrointestinal: Diarrhea, nausea and vomiting.
  Blood: High concentration of eosinophils, platelet counts in the blood, decrease in white blood cells, low prothrombin levels, bleeding.
  Lab tests: Increase in liver enzyme, elevated BUN (Blood urea, nitrogen).
  Local: Indurations/tightness/warmth.
  Genitourinary: Vaginal inflammation.
  Miscellaneous: Fatal ceftriaxone-calcium precipitates in lung and kidneys of neonates.

What are the other precautions for Ceftriaxone?

Caution is needed in patients with:
• Hemolytic anemia
• Kidney problems
• Liver problems

What are the Drug Interactions of Ceftriaxone?

Do not take Ceftriaxone with:
• Vancomycin
• Amsacrine
• Aminoglycosides
• Fluconazole
• Calcium-containing products

What are the storage conditions for Ceftriaxone?

Injection: Store below 25°C. Store it at room temperature and keep away from children.
Last Updated : 12-0ct-2021



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Comments

nightnurse, Bulgaria

My daughter was recently prescribed this antibiotic for a lung infection. I told the hospital that she is a hemophilia suffer as well as a carrier, last night she reported tome that she has seen blood in the urine ! I just looked up the contraindications and saw a side effect of "Bleeding" Why do hospital doctors not check the complications out ? :[

rajan5, India

a woman patient 70 year old given 2 gram monocef while being on calcium tabs. The BP dropped to 40 upper with no lower bp. Patient advised angioplasty. Pl advise

amitarora00786, N/A

INJECTION MONOCEF 1 GM (CEFTRIAXONE) CAN CAUSE OF INTESTINE DAMAGE OR LEAK IF YES WHY ? CAUSES OF INTESTINE DAMAGE DURING CEFTRAIXONE.

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