This medication is prescribed for depression and smoking cessation. It increases the levels of certain chemicals in the brain and reduces the cravings, anxiety, irritability and other symptoms associated with depression.
Contraindicated in patients who are allergic to bupropion, history of convulsions, eating disorders, with MAO inhibitors or those who are planning to stop sedatives or alcohol suddenly.
Adult: Modified-release preparation: Initially, 150 mg once daily for 6 days then increased to 150 mg twice a day. Period of treatment: 7-12 wk. Elderly: 150 mg/day.
Depression Adult: Initially, 100 mg twice a day increased to 100 mg three times a day after 3 days if necessary. Increase further to 150 mg twice a day if no improvement has been observed after several week of therapy.
It comes as a tablet and a sustained-release or extended-release (long-acting) tablet to take by mouth, without meals.
Increased heart rate, abnormal heart rhythm, flushing, hypertension, hot flashes and chest pain.
• Central Nervous System: Headache, agitation, sleeplessness, dizziness, tremor, sedation, disturbed concentration, anxiety, confusion, hostility, fatigue, nervousness, loss of energy, impaired sleep quality, migraine, sensory disturbances, abnormal dreams, decreased memory, feeling jittery and irritability.
• Skin: Sweating, rash, itching and hives.
• Eye and ENT: Blurred vision, inflammation of the nasopharynx, sensation of buzzing, ringing, clicking, double vision, deafness and increased eye pressure.
• Gastrointestinal: Dry mouth, constipation, loss of appetite, nausea, abdominal pain, diarrhea, flatulence, taste perversion, vomiting, indigestion and difficulty in swallowing.
• Genitourinary: Menstrual complaints, urinary frequency, impotence, urinary retention, vaginal bleeding, urinary tract infection, abnormal ejaculation and decreased sexual activity.
• Blood: Altered Prothrombin Time, anemia, bruising, transient increase in white blood cells, deficiency of all three cell elements of the blood, erythrocytes, leukocytes and platelets.
• Liver: Inflammation of the liver and liver damage.
• Metabolic: Weight loss, in some people weight gain and glucose in urine.
• Musculoskeletal: Muscle pain, joint pain, inflammation of joints, pain in extremity, muscle spasm, twitch muscle rigidity and muscle weakness.
• Respiratory: Upper respiratory tract infection, sinusitis, cough and pneumonia.
• Miscellaneous: Infection, fever and hypersensitivity reaction.
Monitor BP before and after treatment; monitor weekly if used with nicotine products.
Oral: Store at 15-25°C. Store it in airtight container and keep away from children.