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General Information on Bupropion

Generic Name : Bupropion

Pronunciation : byoo proe' pee on

Latest prescription information about Bupropion. Learn how to pronounce the drug's name, its indications, dosage, how to take, when to take, when not to take, side effects, special precautions, its storage instructions and warnings if any when taken during pregnancy. Also listed are the International and Indian trade name(s) of the drug and its price list.
ICD Code : Y49.2 | Therapeutic Classification : Psychotherapeutics

Trade Names/Brand Names of Bupropion

India : 

International : 

Aplenzin , Budeprion XL , Zyban , Wellbutrin , Wellbutrin SR

Why is Bupropion Prescribed? (Indications)

This medication is prescribed for depression and smoking cessation. It increases the levels of certain chemicals in the brain and reduces the cravings, anxiety, irritability and other symptoms associated with depression.  

When should Bupropion not to be taken? (Contraindications)

Contraindicated in patients who are allergic to bupropion, history of convulsions, eating disorders, with MAO inhibitors or those who are planning to stop sedatives or alcohol suddenly.

What is the dosage of Bupropion?

Oral- Smoking cessation- Adult: Modified-release preparation: Initially, 150 mg once daily for 6 days then increased to 150 mg twice a day. Period of treatment: 7-12 wk. Elderly: 150 mg/day.
Depression Adult: Initially, 100 mg twice a day increased to 100 mg three times a day after 3 days if necessary. Increase further to 150 mg twice a day if no improvement has been observed after several week of therapy.

How should Bupropion be taken?

It comes as a tablet and a sustained-release or extended-release (long-acting) tablet to take by mouth, without meals.

What are the warnings and precautions for Bupropion?

Patient may develop suicidal tendencies and seizure.

Avoid using decongestants, stimulants, or diet pills while you are taking this medication. They may increase the risk of seizures.

Do not stop alcohol consumption suddenly.

Don't take this medication while you are using other brands containing bupropion.

Caution needed in patients with history of alcoholism, street drugs use, or overuse prescription medications, heart attack, head injury, tumor in brain or spine; high blood pressure, diabetes or liver, kidney or heart disease, seizure disorders, bipolar disorders unstable heart disease and pregnancy.

It may make you drowsy. Do not drive a car or operate machinery while taking this medication.

What are the side effects of Bupropion?

  Heart: Increased heart rate, abnormal heart rhythm, flushing, hypertension, hot flashes and chest pain.
  Central Nervous System: Headache, agitation, sleeplessness, dizziness, tremor, sedation, disturbed concentration, anxiety, confusion, hostility, fatigue, nervousness, loss of energy, impaired sleep quality, migraine, sensory disturbances, abnormal dreams, decreased memory, feeling jittery and irritability.
  Skin: Sweating, rash, itching and hives.
  Eye and ENT: Blurred vision, inflammation of the nasopharynx, sensation of buzzing, ringing, clicking, double vision, deafness and increased eye pressure.
  Gastrointestinal: Dry mouth, constipation, loss of appetite, nausea, abdominal pain, diarrhea, flatulence, taste perversion, vomiting, indigestion and difficulty in swallowing.
  Genitourinary: Menstrual complaints, urinary frequency, impotence, urinary retention, vaginal bleeding, urinary tract infection, abnormal ejaculation and decreased sexual activity.
  Blood: Altered Prothrombin Time, anemia, bruising, transient increase in white blood cells, deficiency of all three cell elements of the blood, erythrocytes, leukocytes and platelets.
  Liver: Inflammation of the liver and liver damage.
  Metabolic: Weight loss, in some people weight gain and glucose in urine.
  Musculoskeletal: Muscle pain, joint pain, inflammation of joints, pain in extremity, muscle spasm, twitch muscle rigidity and muscle weakness.
  Respiratory: Upper respiratory tract infection, sinusitis, cough and pneumonia.
  Miscellaneous: Infection, fever and hypersensitivity reaction.

What are the other precautions for Bupropion?

Monitor BP before and after treatment; monitor weekly if used with nicotine products.

What are the storage conditions for Bupropion?

Oral: Store at 15-25C. Store it in airtight container and keep away from children.

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