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Drug information on Zyban (150mg) (Bupropion) from Glaxo SmithKline Pharmaceuticals Ltd.

Zyban (150mg)

Glaxo SmithKline Pharmaceuticals Ltd.
Generic : Bupropion
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Medical Condition(s) for which Zyban (150mg) may be prescribed

Side effects of Zyban (150mg)

  Heart: Increased heart rate, abnormal heart rhythm, flushing, hypertension, hot flashes and chest pain.

  Central Nervous System: Headache, agitation, sleeplessness, dizziness, tremor, sedation, disturbed concentration, anxiety, confusion, hostility, fatigue, nervousness, loss of energy, impaired sleep quality, migraine, sensory disturbances, abnormal dreams, decreased memory, feeling jittery and irritability.

  Skin: Sweating, rash, itching and hives.

  Eye and ENT: Blurred vision, inflammation of the nasopharynx, sensation of buzzing, ringing, clicking, double vision, deafness and increased eye pressure.

  Gastrointestinal: Dry mouth, constipation, loss of appetite, nausea, abdominal pain, diarrhea, flatulence, taste perversion, vomiting, indigestion and difficulty in swallowing.

  Genitourinary: Menstrual complaints, urinary frequency, impotence, urinary retention, vaginal bleeding, urinary tract infection, abnormal ejaculation and decreased sexual activity.

  Blood: Altered Prothrombin Time, anemia, bruising, transient increase in white blood cells, deficiency of all three cell elements of the blood, erythrocytes, leukocytes and platelets.

  Liver: Inflammation of the liver and liver damage.

  Metabolic: Weight loss, in some people weight gain and glucose in urine.

  Musculoskeletal: Muscle pain, joint pain, inflammation of joints, pain in extremity, muscle spasm, twitch muscle rigidity and muscle weakness.

  Respiratory: Upper respiratory tract infection, sinusitis, cough and pneumonia.

  Miscellaneous: Infection, fever and hypersensitivity reaction.

Dosage & When it is to be taken (Indications)

Oral- Smoking cessation- Adult: Modified-release preparation: Initially, 150 mg once daily for 6 days then increased to 150 mg twice a day. Period of treatment: 7-12 wk. Elderly: 150 mg/day.
Depression Adult: Initially, 100 mg twice a day increased to 100 mg three times a day after 3 days if necessary. Increase further to 150 mg twice a day if no improvement has been observed after several week of therapy.

How to use Zyban (150mg)?

It comes as a tablet and a sustained-release or extended-release (long-acting) tablet to take by mouth, without meals.

When is Zyban (150mg) not to be taken? (Contraindications)

Contraindicated in patients who are allergic to bupropion, history of convulsions, eating disorders, with MAO inhibitors or those who are planning to stop sedatives or alcohol suddenly.

Warnings and Precautions for Zyban (150mg)

Patient may develop suicidal tendencies and seizure.

• Avoid using decongestants, stimulants, or diet pills while you are taking this medication. They may increase the risk of seizures.

• Do not stop alcohol consumption suddenly.

• Don't take this medication while you are using other brands containing bupropion.

• Caution needed in patients with history of alcoholism, street drugs use, or overuse prescription medications, heart attack, head injury, tumor in brain or spine; high blood pressure, diabetes or liver, kidney or heart disease, seizure disorders, bipolar disorders unstable heart disease and pregnancy.

• It may make you drowsy. Do not drive a car or operate machinery while taking this medication.

Other Precautions for Zyban (150mg)

Monitor BP before and after treatment; monitor weekly if used with nicotine products.

Storage Conditions for Zyban (150mg)

Oral: Store at 15-25°C. Store it in airtight container and keep away from children.

♦ Safety Labeling Changes Approved By FDA

Disclaimer : The Price of the drugs indicated above may not match the actual price at which they are sold. Prices can change depending on many factors, including GST. These are only approximate indicative prices of the drug.
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Substitutes for Zyban (150mg)

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