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General Information on Bosentan

Generic Name : Bosentan

Pronunciation : boe sen' tan

Latest prescription information about Bosentan. Learn how to pronounce the drug's name, its indications, dosage, how to take, when to take, when not to take, side effects, special precautions, its storage instructions and warnings if any when taken during pregnancy. Also listed are the International and Indian trade name(s) of the drug and its price list.
ICD Code : Y52.3 | Therapeutic Classification : Vasodilators

Trade Names/Brand Names of Bosentan

Why is Bosentan Prescribed? (Indications)

This medication is an endothelin receptor antagonist, prescribed for pulmonary atrial hypertension (high blood pressure in the lungs). The medication blocks the effects of endothelin-1 thereby decreases blood pressure in lungs. The medication also inhibits blood vessel thickening. 

When should Bosentan not to be taken? (Contraindications)

Contraindicated in pregnant women, co-administration with cyclosporine A and glyburide may increase the risk of liver damage; hypersensitivity.

What is the dosage of Bosentan?

Initial: The recommended dose is 62.5 mg twice daily for 4 weeks. Maintenance dose is 125 mg twice daily.

How should Bosentan be taken?

It comes as a tablet to take by mouth, with or without food.

What are the warnings and precautions for Bosentan?

• Caution should be exercised in patients with history of heart disease, liver disease and anemia.

• It may cause dizziness or drowsiness, do not drive a car or operate machinery while taking this medication.

• During the treatment monitor the level of hemoglobin regularly.

• Avoid pregnancy while taking this medication by using proper birth control methods.

• Patient may develop oligohidrosis(absence of sweating) or high body temperature. If it is so consult with your healthcare provider.

What are the side effects of Bosentan?

•  Most Common: Respiratory tract infection, nausea, stomach pain, loss of appetite, chest pain, fainting, low blood pressure, palpitation and anemia.
•  Central Nervous System : Headache, dizziness and tiredness.
•  Gastrointestinal: Diarrhea.
•  Genitourinary : Reduced sperm count.
•  Miscellaneous: Liver failure, rash, jaundice and joint pain.

What are the other precautions for Bosentan?

Avoid alcoholic beverages.

What are the storage conditions for Bosentan?

Store it at room temperature (20ēC – 25ēC), and in an airtight container.

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