This medication is an endothelin receptor antagonist, prescribed for pulmonary atrial hypertension (high blood pressure in the lungs). The medication blocks the effects of endothelin-1 thereby decreases blood pressure in lungs. The medication also inhibits blood vessel thickening.
Contraindicated in pregnant women, co-administration with cyclosporine A and glyburide may increase the risk of liver damage; hypersensitivity.
Initial: The recommended dose is 62.5 mg twice daily for 4 weeks. Maintenance dose is 125 mg twice daily.
It comes as a tablet to take by mouth, with or without food.
Caution should be exercised in patients with history of heart disease, liver disease and anemia.
It may cause dizziness or drowsiness, do not drive a car or operate machinery while taking this medication.
During the treatment monitor the level of hemoglobin regularly.
Avoid pregnancy while taking this medication by using proper birth control methods.
♦Patient may develop oligohidrosis(absence of sweating) or high body temperature. If it is so consult with your healthcare provider.
Respiratory tract infection, nausea, stomach pain, loss of appetite, chest pain, fainting, low blood pressure, palpitation and anemia.
Central Nervous System : Headache, dizziness and tiredness.
Genitourinary : Reduced sperm count.
Miscellaneous: Liver failure, rash, jaundice and joint pain.
Avoid alcoholic beverages.
Store it at room temperature (20ēC 25ēC), and in an airtight container.
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