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Lupibose (125mg) is an endothelin receptor antagonist, prescribed for pulmonary atrial hypertension (high blood pressure in the lungs). The medication blocks the effects of endothelin-1 thereby decreases blood pressure in lungs. The medication also inhibits blood vessel thickening. 

Drug information on Lupibose (125mg) (Bosentan) from Lupin Laboratories Ltd. (Pinnacle)

Lupibose (125mg)

  Film coated tablet
Lupin Laboratories Ltd. (Pinnacle)
Generic : Bosentan
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Medical Condition(s) for which Lupibose (125mg) may be prescribed

Side effects of Lupibose (125mg)

  Most Common: Respiratory tract infection, nausea, stomach pain, loss of appetite, chest pain, fainting, low blood pressure, palpitation and anemia.

  Central Nervous System : Headache, dizziness and tiredness.

  Gastrointestinal: Diarrhea.

  Genitourinary : Reduced sperm count.

  Miscellaneous: Liver failure, rash, jaundice and joint pain.

Dosage & When it is to be taken (Indications)

Initial: The recommended dose is 62.5 mg twice daily for 4 weeks. Maintenance dose is 125 mg twice daily.

How to use Lupibose (125mg)?

It comes as a tablet to take by mouth, with or without food.

When is Lupibose (125mg) not to be taken? (Contraindications)

Contraindicated in pregnant women, co-administration with cyclosporine A and glyburide may increase the risk of liver damage; hypersensitivity.

Warnings and Precautions for Lupibose (125mg)

Caution should be exercised in patients with history of heart disease, liver disease and anemia.

• It may cause dizziness or drowsiness, do not drive a car or operate machinery while taking this medication.

• During the treatment monitor the level of hemoglobin regularly.

• Avoid pregnancy while taking this medication by using proper birth control methods.

Patient may develop oligohidrosis(absence of sweating) or high body temperature. If it is so consult with your healthcare provider.

Other Precautions for Lupibose (125mg)

Avoid alcoholic beverages.

Storage Conditions for Lupibose (125mg)

Store it at room temperature (20ºC – 25ºC), and in an airtight container.

♦ Safety Labeling Changes Approved By FDA

Disclaimer : The Price of the drugs indicated above may not match the actual price at which they are sold. Prices can change depending on many factors, including GST. These are only approximate indicative prices of the drug.
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Substitutes for Lupibose (125mg)

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