Pallavi Singh
Written & Compiled by Pharmacist Pallavi Singh, M. Pharmacy (Pharmacy Practice)
Dr. Simi Paknikar
Medically Reviewed by Dr. Simi Paknikar, MD
Last Updated on Oct 12, 2017
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General Information on Amiloride

Generic Name : Amiloride

Pronunciation : a-MIL-oh-ride

Latest prescription information about Amiloride. Learn how to pronounce the drug's name, its indications, dosage, how to take, when to take, when not to take, side effects, special precautions, warnings and its storage instructions . Also listed are the International and Indian trade name(s) of the drug and its price list.
Therapeutic Classification : Diuretics

Trade Names/Brand Names of Amiloride

India : 

International : 


Overview of Amiloride

• Amiloride is a water pill or a diuretic that causes the body to get rid of extra salt and water, without causing excess loss of potassium or hypokalemia.

Why is Amiloride Prescribed? (Indications)

Amiloride is a potassium-sparing diuretic or water pill. It brings about fluid loss via the kidneys without causing potassium loss. It is used with other diuretics to treat high blood pressure (hypertension),  heart failure, or accumulation of extra fluid in the body (edema).

It prevents low blood potassium levels when used the other diuretics. Amiloride may be used alone to increase blood potassium levels with regular monitoring in those with persistent low levels.  

When should Amiloride not to be taken? (Contraindications)

Amiloride is contraindicated in patients with

• Hyperkalemia (high potassium levels), kidney impairment, anuria (absence of urine formation), diabetic kidney disease .
• Allergy to the drug
• Intake of other potassium sparing drugs like spironolactone , and potassium supplements, as well as salt substitutes.

What is the dosage of Amiloride?

• The recommended dosage of amiloride is one tablet of 5 mg per day, which can be increased to 10 mg per day if necessary.

• In case the hypokalemia (low blood potassium) persists, the dose can be increased to 15mg, and then 20 mg, but with careful monitoring of the electrolyte levels.

How should Amiloride be taken?

If the drug is taken too close to bedtime, the patient will need to wake up to urinate thereby disturbing his/her sleep, so it is best to take medication at least 4 hours before bedtime.

What are the warnings and precautions for Amiloride?

• Liver enzymes should be monitored in patients with liver impairment on amiloride. Amiloride is not recommended for nursing mothers.

• Serum potassium levels should be monitored during treatment.

• Amiloride should be avoided in diabetes patients or patients at a high risk of acidosis. It may also interfere with the results of glucose tolerance test.

What are the side effects of Amiloride?

  General: Rash, weakness
  Gastrointestinal: Nausea, loss of appetite, pain in the abdomen, excess gas
  Blood: Hyperkalemia, hyponatremia (low blood sodium levels), hypochloremia (low blood chloride levels)
  Kidney: Increase in blood urea nitrogen
  Nervous system: Headache, encephalopathy in patients with severe liver disease, dizziness
  Respiratory system: Cough, breathlessness
  Reproductive system: Impotence

What are the other precautions for Amiloride?

• Check with your doctor right away if you experience numbness or tingling in the hands, feet, or lips, weakness or heaviness and paralysis of the legs, slow heart rate or extremely low blood pressure as these could be signs of hyperkalemia.

What are the Drug Interactions of Amiloride?

• Hyperkalemia may occur if amiloride is administered with potassium-sparing diuretics like spironolactone and triamterene, ACE inhibitors, potassium supplements, indomethacin, cyclosporine or tacrolimus
• Amiloride may increase lithium levels resulting in lithium toxicity
• NSAIDs can reduce the diuretic effect of amiloride

What are the storage conditions for Amiloride?

• Store tablets at controlled room temperature (20° to 25°C), protect from moisture, freezing, and excessive heat.

Last Updated : 10/11/2017

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