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Amiloride is a potassium-sparing diuretic or water pill. It brings about fluid loss via the kidneys without causing potassium loss. It is used with other diuretics to treat high blood pressure (hypertension),  heart failure, or accumulation of extra fluid in the body (edema).

It prevents low blood potassium levels when used the other diuretics. Amiloride may be used alone to increase blood potassium levels with regular monitoring in those with persistent low levels.  

Drug information on Biduret- L (2.5mg/25mg) (Amiloride 2.5mg + Hydrochlorothiazide 25mg) from Glaxo SmithKline Pharmaceuticals Ltd.

Biduret- L (2.5mg/25mg)

  Tablet  
Glaxo SmithKline Pharmaceuticals Ltd.
Generic : Amiloride
 17.72
2.5mg/25mg
10
Combination of Generics : Amiloride 2.5mg + Hydrochlorothiazide 25mg
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Side effects of Amiloride

  General: Rash, weakness

  Gastrointestinal: Nausea, loss of appetite, pain in the abdomen, excess gas

  Blood: Hyperkalemia, hyponatremia (low blood sodium levels), hypochloremia (low blood chloride levels)

  Kidney: Increase in blood urea nitrogen

  Nervous system: Headache, encephalopathy in patients with severe liver disease, dizziness

  Respiratory system: Cough, breathlessness

  Reproductive system: Impotence

When is Amiloride not to be taken? (Contraindications)

Amiloride is contraindicated in patients with

• Hyperkalemia (high potassium levels), kidney impairment, anuria (absence of urine formation), diabetic kidney disease .
• Allergy to the drug
• Intake of other potassium sparing drugs like spironolactone , and potassium supplements, as well as salt substitutes.


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