Written & Compiled by Anushta Chandrapalan, M.Sc  | Medically Reviewed by The Medindia Medical Review Team on Sep 20, 2013
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General Information on Acetazolamide

Generic Name : Acetazolamide

Pronunciation : (a set a zole'a mide)

Latest prescription information about Acetazolamide. Learn how to pronounce the drug's name, its indications, dosage, how to take, when to take, when not to take, side effects, special precautions, warnings and its storage instructions . Also listed are the International and Indian trade name(s) of the drug and its price list.
ICD Code : Y54.5 | Therapeutic Classification : Diuretics

Why is Acetazolamide Prescribed? (Indications)

Acetazolamide is prescribed to treat excess fluid accumulation due to congestive heart failure.

It is also used to treat glaucoma or increased pressure in the eye, seizures or epilepsy, mountain sickness, periodic paralysis or muscle weakness, and to reduce the increased pressure in areas surrounding the brain and spinal cord. 

When should Acetazolamide not to be taken? (Contraindications)

Contraindicated in patients with adrenal gland problems, low levels of potassium or sodium in blood, kidney problems, liver problems, high levels of chloride in blood, electrolyte problems and hypersensitivity.

What is the dosage of Acetazolamide?

The dose ranges from 250 mg to 1 g of acetazolamide for 24 hours, usually in divided doses for amounts over 250 mg.
Adult- PO Diuresis 250-375 mg/day. Glaucoma; Epilepsy 250-1,000 mg/day. Prophylaxis of high altitude sickness 500-1,000 mg/day. IV Chronic open angle glaucoma 250-1000 mg 24 hrly and Epilepsy 8-30 mg/kg/day in divided doses.

How should Acetazolamide be taken?

It comes as a tablet and capsule, to take by mouth with food. If you are taking the extended-release form of acetazolamide, do not crush or chew the capsules.

What are the warnings and precautions for Acetazolamide?

Caution should be exercised in patients with history of kidney stones, sickle cell anemia, lung diseases, increased eye pressure, respiratory problem, elderly, who are taking other medications, any allergy, during pregnancy and breastfeeding.

It may cause dizziness, drowsiness or vision changes, do not drive a car or operate machinery while taking this medication.

Limit alcoholic beverages.

Avoid exposure to sunlight.

Monitor blood sugar, complete blood cell count regularly while taking this medication.

This medication should not be used in children less than 12 because it may affect normal growth.

Caution is advised for patients receiving concomitant high-dose aspirin and acetazolamide, as anorexia, tachypnea, lethargy, coma and death have been reported.

What are the side effects of Acetazolamide?

   Most Common : Numbness and tingling in the fingers and toes, tiredness, loss of appetite,dry mouth, headache, nausea, vomiting, stomach pain.
  Central Nervous System: Occasional instances of drowsiness and confusion, and seizures.
  ENT: Taste alterations (parageusia) especially for carbonated drinks, sore throat, ringing in the ear, and Some may also experience blurred vision but this usually disappears shortly after discontinuing the medication.
  Genitourinary: Blood in stool/urine, dark urine, painful urination and excessive passage of urination.
  Metabolic: Liver impairment, increases the risk of kidney stones, metabolic acidosis, increased thirst, and electrolyte imbalance.
  Skin: Hives, unusual bleeding or bruising and photosensitivity.

What are the other precautions for Acetazolamide?

Avoid excess dosage.

What are the storage conditions for Acetazolamide?

Store at 20-25C (68-77F). Excursions permitted to 15-30 in an airtight container. Keep it out of reach of children.

Last Updated : Jul 2018

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