The heart is made up of four chambers: two atria and two ventricles. The ventricles make up the lower chambers of the heart. They pump blood during the contraction of the muscles. This event is called systole. After each ventricular contraction (systole) the ventricle muscles take some time to relax during which blood from the upper chambers (atria) fills them. This is the diastole.
A number of conditions cause diminished pumping ability of the ventricles. Heart attacks and infections (myocarditis) weaken the ventricular muscles leading to systolic dysfunction.
Congestive heart failure can be caused by:
- Diseases in which the heart muscle weakens
- Diseases in which the heart muscles stiffens
- Conditions where oxygen demand by the body tissue is beyond the capacity of the heart (It is the heart that has to deliver adequate oxygen-rich blood)
In some patients the pumping action remains normal but the body requirements are much higher than what the heart can deliver. Conditions like anaemia or hyperthyroidism are often responsible for this.
In some individuals one or more of these factors can co-exist and may present as a congestive heart failure. Let us focus on the congestive heart failure that is due to heart muscle weakness, i.e. systolic dysfunction.
What is new in congestive heart failure?
1. Heart Failure and Cardiac Cell Death can be Brought to a StopInhibition of OMA1 which activates heart stress could be targeted for the prevention of heart failure finds a new study. The elimination of OMA1 prevented heart failure demonstrating a direct role in the protection of cardiomyocytes (the muscle cells of the heart). This assures the scientists that OMA1 can be a promising target for the treatment of heart failure.Read More..
References:1. Cecil Medicine, 23rd Ed.
2. Harrison''s PRINCIPLES OF INTERNAL MEDICINE, 17TH Edition
3. Amsterdam EA. Revised American College of Cardiology/American Heart Association guidelines for the management of heart failure. Prev Cardiol. 2005 Fall;8(4):254, 256.
4. Heart Failure Society Of America. Evaluation and management of patients with acute decompensated heart failure. J Card Fail. 2006 Feb;12(1):e86-e103. Review.
Latest Publications and Research on Congestive Heart FailureRestrictive Spirometry Pattern, Cardiac Structure and Function, and Incident Heart Failure in African-Americans: The Jackson Heart Study. - Published by PubMed
Immediate impact of percutaneous transvenous mitral commisurotomy on right ventricle longitudnal strain in patients of mitral stenosis. - Published by PubMed
The diagnostic and prognostic value of copeptin in cardiovascular disease, current status, and prospective. - Published by PubMed
Identification of potential pathogenic viruses in patients with acute myocarditis using next-generation sequencing. - Published by PubMed
Cardiac Resynchronization is Pro-arrhythmic in the Absence of Reverse Ventricular Remodelling: A Systematic Review and Meta-analysis. - Published by PubMed