It is a condition in which the pancreas produces insulin but the body cannot use it because it becomes resistant to the action of insulin. However, Dr. Barry Groves, the British nutritionist and an international author, defines type-2 diabetes as ‘a clinical syndrome characterized by chronic hyperglycemia due to an excessive intake of carbohydrate’ because ‘carbohydrate is the only dietary component that puts glucose into the blood’.
So, what exactly is the link between carbohydrates and type-2 diabetes? Simply put, eating carbohydrates triggers insulin, and too much of carbohydrates cause insulin resistance. However, all types of carbohydrates are not responsible for insulin resistance and type-2 diabetes. It is the monosaccharide or the sugary carbs that are the main culprits.
Sugary carbs, including sugar-sweetened beverages, have high glycemic index (GI) that raise blood glucose levels in the body very quickly causing a ‘spike’. In response, the pancreas tries to keep up with insulin requirement and releases more insulin very rapidly to help cells absorb the ‘extra’ glucose. A time comes when the pancreas cannot keep up with the demand for insulin.
The National Institutes of Health suggests that we should get 40 -60 percent of total calories from carbohydrates, and that too, from complex carbohydrates like starchy vegetables, whole grains and legumes, and natural sugars that are found in milk, fruits and vegetables. This is because these natural sugars are simple carbohydrates that contain naturally occurring vitamins and minerals.
Refined sugars such as table sugar, sweetened beverages, syrups (including high fructose corn syrup or HFCS) and candy do provide calories but these are ‘empty’ calories since they do not contain fiber, vitamins and minerals. Empty calories lead to weight gain, which finally leads to a cluster of conditions called metabolic syndrome causing obesity, high blood pressure and type-2 diabetes.
- Insulin resistance - (http://www.diabetes.niddk.nih.gov/dm/pubs/insulinresistance/)
- Bray GA, Nielsen SJ, Popkin BM. Consumption of high-fructose corn syrup in beverages may play a role in the epidemic of obesity. Am J Clin Nutr. 2004 Apr;79(4):537-43.
- Ferder, L. et al. The Role of High-Fructose Corn Syrup in Metabolic Syndrome and Hypertension. Current Hypertension Reports Volume 12, Number 2, 105-112, DOI: 10.1007/s11906-010-0097-3
- Nagai et al. The Role of Peroxisome Proliferator-Activated Receptor Coactivator-1 in the Pathogenesis of Fructose-Induced Insulin Resistance. Cell Metabolism, 2009; 9 (3): 252-264
- Welsh J.A., et al. Caloric Sweetener Consumption and Dyslipidemia Among US Adults. JAMA. 2010;303(15):1490-1497. doi: 10.1001/jama.2010.449
- SSB, obesity - (http://depts.washington.edu/epidem/Epi591/Editorial%20For%205-27-10.pdf)
- 1st study - (http://care.diabetesjournals.org/content/33/11/2477.full)
- 2nd study - Schulze MB,Manson JE, Ludwig DS, et al. Sugar-sweetened beverages, weight gain, and incidence of type 2 diabetes in young and middle-aged women. JAMA. 2004;292:927-934.
Latest Publications and Research on Diabetes Type 2 and Its Link to Sugar-Sweetened BeveragesThe effect of exercise training on intrahepatic triglyceride and hepatic insulin sensitivity: a systematic review and meta-analysis. - Published by PubMed
Molecular Property Diagnostic Suite for Diabetes Mellitus (MPDSDM): An Integrated Web Portal for Drug Discovery and Drug Repurposing. - Published by PubMed
Lysine glycation of apolipoprotein A-I impairs its anti-inflammatory function in type 2 diabetes mellitus. - Published by PubMed
Low linolenic and linoleic acid consumption are associated with chronic kidney disease in patients with type 2 diabetes. - Published by PubMed
Effects of Clove and Fermented Ginger on Blood Glucose, Leptin, Insulin and Insulin Receptor Levels in High Fat DietInduced Type 2 Diabetic Rabbits. - Published by PubMed