Although the ketogenic diet has been lauded for weight loss and improving blood sugar control, a new animal study finds that women fail to show these metabolic gains on this high-fat, very low-carbohydrate diet. The findings of the study will be presented at the Endocrine Society's annual meeting.
"These results may help explain discrepancies in this diet's success rates across the sexes."
Originally used as a treatment for epilepsy, the ketogenic diet, which is sometimes called the keto diet, greatly restricts consumption of carbohydrates (starches, sugars, and fibers) and proteins. This makes the body switch from burning carbohydrates for energy, which it does naturally, to burning stored fat. The liver converts fat to ketone bodies in a process called ketosis.
Working under Abel's supervision, Cochran studied both male and female mice. He fed them either a ketogenic diet or a regular diet as a control. The control diet consisted of 7 percent fat, 47 percent carbohydrates and 19 percent protein by mass, whereas the keto diet was 75 percent fat, 3 percent carbohydrates and 8 percent protein by mass. After 15 weeks of feeding, the female mice on the ketogenic diet displayed no changes in weight and had impaired blood sugar control compared with females on the control diet, he reported.
In male mice, however, body weight decreased on the ketogenic diet while blood sugar control was maintained. However, males on the ketogenic diet displayed signs of worsened non-alcoholic fatty liver disease.
Speculating that estrogen plays a role in the differing response to the ketogenic diet, Cochran removed the ovaries of some female mice and tested both diets. Compared to mice fed a control diet, ovariectomized mice on a ketogenic diet had decreased body weight and body fat.
"This finding suggests that postmenopausal women could potentially experience better weight loss outcomes with the ketogenic diet compared to younger women," Cochran said.
Abel recommended that people considering a ketogenic diet discuss it with their doctor or a dietitian first, noting that some feel worse while on this diet or have trouble sticking to it.