Scientists at US Dana-Farber Cancer Institute have found a new way to weaken the protein that is thought to play an important role in leukemia and other cancers.
The protein in question, called Notch, is often found to be damaged or mutated in patients with a form of blood cancer known as T-cell acute lymphoblastic leukemia (ALL), reports the BBC.
Survival in High-risk Childhood Leukaemia Patients Increased by Drug-Chemo Combination
Daily doses of a targeted drug called imatinib mesylate along with regular chemotherapy can almost double the survival rate of children with leukemia
Daily doses of a targeted drug called imatinib mesylate along with regular chemotherapy can almost double the survival rate of children with leukemia
They employed a state-of-the-art technique, using chemical braces to mould protein snippets called peptides, into specific three-dimensional shapes.
These ’stapled’ peptides are readily absorbed by cells, and are so tiny they can be deployed to alter gene regulation at specific sites.
Researchers Discover Genetic 'Switch' That Triggers Leukaemia
Researchers identified a broken genetic switch that can trigger leukaemia.
Researchers identified a broken genetic switch that can trigger leukaemia.
When tested in mice, it was found to limit the growth of cancer cells. Analysis showed that activity was depressed in genes, both directly and indirectly controlled by Notch.
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Australian Researchers Discover Cell Receptor Behind Leukaemia
Australian researchers report discovery of a cell receptor that could be behind diseases like leukaemia. This could in turn become the springboard for development of new treatments.
Australian researchers report discovery of a cell receptor that could be behind diseases like leukaemia. This could in turn become the springboard for development of new treatments.
The study features in the journal Nature.
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Leukaemia Treatment may be Revolutionized by Enzyme Modification
A team of Canadian researchers have re-engineered a human enzyme to become highly resistant to harmful agents such as chemotherapy.
A team of Canadian researchers have re-engineered a human enzyme to become highly resistant to harmful agents such as chemotherapy.
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