A team of Canadian researchers have re-engineered a human enzyme to become highly resistant to harmful agents such as chemotherapy. This promises to revolutionize leukemia therapy. Scientists at the Universite de Montreal and McGill University made this breakthrough as they sought ways to help correct genetic diseases. "Our team modified and decoded an enzyme structure," says Joelle Pelletier, a professor at the Universite de Montreal's Department of Chemistry. "We discovered, to our surprise, that our intervention allowed the heart of the enzyme to increase its mobility. This unusual mobility caused the enzyme to resist the chemotherapy agent methotrexate - a result we never predicted and one that offers promise. "Our goal is to improve the injection of corrective genes in people suffering from genetic diseases. This discovery will lead to promising new avenues," Pelletier added. Albert Berghuis, a professor at the McGill University Department of Biochemistry and Canada Research Chair in Structural Biology, said: "We were intrigued to find the enzyme's internal flexibility was impacted by our modifications and that this fact played such a crucial role for resistance." "We can now harness this insight to further advance therapies for genetic diseases such as leukaemia," Berghuis added. The study has been published in The Journal of Biological Chemistry.Source: ANIRAS << Computer Model to Predict Odds of Cancer Recurrence After R... Study Links Exposure to Common Household Pesticides to Chil... >> Recommended Reading Leukemia Encyclopedia section of medindia gives general information about Leukemia READ MORE Acute Lymphoblastic Leukemia Acute lymphoblastic leukemia (ALL) is the cancer of white blood cells characterized by excess lymphoblasts. It is the most common of all childhood cancers and can be fatal in weeks if left untreated. READ MORE Acute Myeloid Leukemia Acute myeloid Leukemia, more popularly known by its abbreviated form AML, is a fast- evolving leukemia that affects both children and adults alike READ MORE Chronic Lymphocytic Leukemia Chronic Lymphocytic Leukemia (CLL) is one of the most common types of adult leukemia and is considered as one of the 'good cancers'. READ MORE Food Preservatives - How Safe Are They? Food preservatives are basically antimicrobials or anti-oxidants that help preserve food by destroying the microbes and stopping decomposition of food products. READ MORE Most Popular on Medindia Blood - Sugar Chart The Essence of Yoga Iron Intake Calculator More News on: Food Preservatives - How Safe Are They?