About Careers Internship MedBlogs Contact us
Medindia LOGIN REGISTER
Advertisement

Leukaemia Treatment may be Revolutionized by Enzyme Modification

by Rajashri on July 31, 2009 at 7:34 PM
Font : A-A+

 Leukaemia Treatment may be Revolutionized by Enzyme Modification

A team of Canadian researchers have re-engineered a human enzyme to become highly resistant to harmful agents such as chemotherapy. This promises to revolutionize leukemia therapy.

Scientists at the Universite de Montreal and McGill University made this breakthrough as they sought ways to help correct genetic diseases.

Advertisement

"Our team modified and decoded an enzyme structure," says Joelle Pelletier, a professor at the Universite de Montreal's Department of Chemistry.

"We discovered, to our surprise, that our intervention allowed the heart of the enzyme to increase its mobility. This unusual mobility caused the enzyme to resist the chemotherapy agent methotrexate - a result we never predicted and one that offers promise.
Advertisement

"Our goal is to improve the injection of corrective genes in people suffering from genetic diseases. This discovery will lead to promising new avenues," Pelletier added.

Albert Berghuis, a professor at the McGill University Department of Biochemistry and Canada Research Chair in Structural Biology, said: "We were intrigued to find the enzyme's internal flexibility was impacted by our modifications and that this fact played such a crucial role for resistance."

"We can now harness this insight to further advance therapies for genetic diseases such as leukaemia," Berghuis added.

The study has been published in The Journal of Biological Chemistry.

Source: ANI
RAS
Advertisement

Advertisement
News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
What's New on Medindia
Test Your Knowledge on Lung Transplantation
Baldness can be Cured and Prevented: let us see How!
Drinking Beer or Wine Every Day Could Cause Age-related Diseases
View all
Recommended Reading
News Archive
Date
Category
Advertisement
News Category

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Food Preservatives - How Safe Are They? 

Most Popular on Medindia

Blood Donation - Recipients How to Reduce School Bag Weight - Simple Tips Diaphragmatic Hernia Turmeric Powder - Health Benefits, Uses & Side Effects Blood - Sugar Chart Sanatogen Blood Pressure Calculator Indian Medical Journals Daily Calorie Requirements Drug Side Effects Calculator
This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use