About My Health Careers Internship MedBlogs Contact us
Medindia LOGIN REGISTER
Advertisement

Survival in High-risk Childhood Leukaemia Patients Increased by Drug-Chemo Combination

by Rajashri on October 8, 2009 at 7:48 PM
Font : A-A+

 Survival in High-risk Childhood Leukaemia Patients Increased by Drug-Chemo Combination

Daily doses of a targeted drug called imatinib mesylate along with regular chemotherapy can almost double the survival rate of children with a high risk type of blood cancer called Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph+ ALL), says a new study.

Known commercially as Gleevec, imatinib is a pill that's used to treat some adult leukemias and gastrointestinal cancers.

Advertisement

It binds to a specific protein in cancer cells and prevents the cells from proliferating.

"With conventional chemotherapy, the three-year survival rate for children with this high-risk type of leukemia is between 30-35 per cent," said Dr. Kirk Schultz, professor of pediatrics at the University of British Columbia.
Advertisement

"Adding continuous exposure to imatinib for two-and-a-half years made a big difference and increased the survival rates to 87 per cent. The drug was well tolerated and it didn't have any significant side effects," he added.

Since traditional chemotherapy doesn't work well for many children with Ph+ ALL, the standard treatment is blood and marrow transplantation, a life-saving procedure that's associated with a risk of complications.

During the study, researchers recruited 92 children and adolescents between one and 21 years of age with Ph+ ALL and to five different groups that received imatinib for different lengths of time.

The group that received imatinib for more than 280 continuous days had survival rates of 87 per cent, a dramatic improvement over traditional chemotherapy and blood and marrow transplantation.

Groups that received imatinib for 84 and 126 days showed moderate improvement in survival rates, while groups receiving the drug for 42 and 63 days had the same survival rates as current standard treatments.

"Using imatinib plus chemotherapy had a synergistic type of interaction," said Schultz.

"I never expected these results. Although it's very promising, we need to do more follow up to get the five-year survival data and determine the long-term survival.

"We submitted our study for publication earlier instead of waiting because the data was so exciting and this type of leukemia is such high risk," he added.

Source: ANI
RAS
Advertisement

Advertisement
News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
News Category
What's New on Medindia
Printed Temperature Sensors help with Continuous Temperature Monitoring
Health Benefits of Giloy
Breast Cancer Awareness Month 2021 - It's time to RISE
View all

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.


Recommended Reading
Leukemia
Encyclopedia section of medindia gives general information about Leukemia...
Acute Lymphoblastic Leukemia
Acute lymphoblastic leukemia (ALL) is the cancer of white blood cells characterized by excess ......
Acute Myeloid Leukemia
Acute myeloid Leukemia, more popularly known by its abbreviated form AML, is a fast- evolving ......
Chronic Myeloid Leukemia
Chronic myeloid Leukemia is one of the most common types of blood cancer. It is characterized by .....

Disclaimer - All information and content on this site are for information and educational purposes only. The information should not be used for either diagnosis or treatment or both for any health related problem or disease. Always seek the advice of a qualified physician for medical diagnosis and treatment. Full Disclaimer

© All Rights Reserved 1997 - 2021

This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use